Corneal photoablation with a scanning beam of 213 nm radiation for alteration of refraction: a three-month follow up study of the rabbit

Per G.M.D. Soederberg, Takaaki Matsui, Fabrice Manns, Jinhui Shen, Jean Marie Parel, Jean Marc M.D. Legeais, Michelle Salvoldelli, Isabelle Drubaix

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

A scanning pulsed beam at 213 nm creates predictable correction of myopia but the surgical procedure with the presently used laser system is not yet sufficiently safe to proceed to human clinical trials. It was found that a 70% overlap of approximate active spot size provides a refractive change as predicted 1 week after ablation. There was a minimal transient increase of IOP shortly after the ablation. There was an immediate swelling of the cornea after the ablation that gradually decreased during the following 12 weeks. The corneal epithelium did not heal until around 4 - 7 weeks after the ablation. The epithelium stained with fluorescein late after the ablation. When considerable haze was seen it decreased towards the end of the 12 weeks of observation. Approximately 30% of ablated corneas showed vessel ingrowth at 12 weeks after ablation. The 213 nm beam was obtained by frequency quintupling of the output of a Nd-Yag laser. The beam was moved with an X-Y scanner.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsRosario Brancato, Adolf F. Fercher, A.S. Melamed, Pascal O. Rol
Pages14-19
Number of pages6
StatePublished - Dec 1 1995
EventLasers in Ophthalmology II - Lille, Fr
Duration: Sep 9 1994Sep 10 1994

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume2330
ISSN (Print)0277-786X

Other

OtherLasers in Ophthalmology II
CityLille, Fr
Period9/9/949/10/94

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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    Soederberg, P. G. M. D., Matsui, T., Manns, F., Shen, J., Parel, J. M., Legeais, J. M. M. D., Salvoldelli, M., & Drubaix, I. (1995). Corneal photoablation with a scanning beam of 213 nm radiation for alteration of refraction: a three-month follow up study of the rabbit. In R. Brancato, A. F. Fercher, A. S. Melamed, & P. O. Rol (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (pp. 14-19). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 2330).