Corneal photoablation with a scanning beam of 213 nm radiation for alteration of refraction: a three-month follow up study of the rabbit

Per G M D Soederberg, Takaaki Matsui, Fabrice Manns, Jinhui Shen, Jean-Marie A Parel, Jean Marc M D Legeais, Michelle Salvoldelli, Isabelle Drubaix

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

A scanning pulsed beam at 213 nm creates predictable correction of myopia but the surgical procedure with the presently used laser system is not yet sufficiently safe to proceed to human clinical trials. It was found that a 70% overlap of approximate active spot size provides a refractive change as predicted 1 week after ablation. There was a minimal transient increase of IOP shortly after the ablation. There was an immediate swelling of the cornea after the ablation that gradually decreased during the following 12 weeks. The corneal epithelium did not heal until around 4 - 7 weeks after the ablation. The epithelium stained with fluorescein late after the ablation. When considerable haze was seen it decreased towards the end of the 12 weeks of observation. Approximately 30% of ablated corneas showed vessel ingrowth at 12 weeks after ablation. The 213 nm beam was obtained by frequency quintupling of the output of a Nd-Yag laser. The beam was moved with an X-Y scanner.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsRosario Brancato, Adolf F. Fercher, A.S. Melamed, Pascal O. Rol
Pages14-19
Number of pages6
Volume2330
StatePublished - Dec 1 1995
EventLasers in Ophthalmology II - Lille, Fr
Duration: Sep 9 1994Sep 10 1994

Other

OtherLasers in Ophthalmology II
CityLille, Fr
Period9/9/949/10/94

Fingerprint

rabbits
Ablation
Refraction
ablation
refraction
Scanning
Radiation
scanning
radiation
cornea
epithelium
myopia
haze
Lasers
swelling
scanners
lasers
vessels
Swelling
output

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Soederberg, P. G. M. D., Matsui, T., Manns, F., Shen, J., Parel, J-M. A., Legeais, J. M. M. D., ... Drubaix, I. (1995). Corneal photoablation with a scanning beam of 213 nm radiation for alteration of refraction: a three-month follow up study of the rabbit. In R. Brancato, A. F. Fercher, A. S. Melamed, & P. O. Rol (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2330, pp. 14-19)

Corneal photoablation with a scanning beam of 213 nm radiation for alteration of refraction : a three-month follow up study of the rabbit. / Soederberg, Per G M D; Matsui, Takaaki; Manns, Fabrice; Shen, Jinhui; Parel, Jean-Marie A; Legeais, Jean Marc M D; Salvoldelli, Michelle; Drubaix, Isabelle.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / Rosario Brancato; Adolf F. Fercher; A.S. Melamed; Pascal O. Rol. Vol. 2330 1995. p. 14-19.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Soederberg, PGMD, Matsui, T, Manns, F, Shen, J, Parel, J-MA, Legeais, JMMD, Salvoldelli, M & Drubaix, I 1995, Corneal photoablation with a scanning beam of 213 nm radiation for alteration of refraction: a three-month follow up study of the rabbit. in R Brancato, AF Fercher, AS Melamed & PO Rol (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 2330, pp. 14-19, Lasers in Ophthalmology II, Lille, Fr, 9/9/94.
Soederberg PGMD, Matsui T, Manns F, Shen J, Parel J-MA, Legeais JMMD et al. Corneal photoablation with a scanning beam of 213 nm radiation for alteration of refraction: a three-month follow up study of the rabbit. In Brancato R, Fercher AF, Melamed AS, Rol PO, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2330. 1995. p. 14-19
Soederberg, Per G M D ; Matsui, Takaaki ; Manns, Fabrice ; Shen, Jinhui ; Parel, Jean-Marie A ; Legeais, Jean Marc M D ; Salvoldelli, Michelle ; Drubaix, Isabelle. / Corneal photoablation with a scanning beam of 213 nm radiation for alteration of refraction : a three-month follow up study of the rabbit. Proceedings of SPIE - The International Society for Optical Engineering. editor / Rosario Brancato ; Adolf F. Fercher ; A.S. Melamed ; Pascal O. Rol. Vol. 2330 1995. pp. 14-19
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