Corneal Perforations: Changing Methods of Treatment, 1960–1980

Lawrence W. Hirst, William E. Smiddy, Walter J. Stark

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


One hundred four nontraumatic corneal perforations or descemetoceles in patients admitted to the Wilmer Institute from 1960 to 1980 were studied retrospectively, with follow-up data obtained from records or from referral physicians for 87 of these perforations. Forty-nine percent of the cases were caused by bacterial corneal ulcers, 13% by exposure, 12% by chemical burns, 6% by fungal keratitis, 5% by herpes simplex keratitis, and 15% were undiagnosed. Since the start of tissue adhesive use at the Wilmer Institute in 1974, there has been an apparent trend towards a lower enucleation rate (6%) in corneal perforations treated with tissue adhesive as compared to 19% in perforations treated by other therapies, although the cases may not be entirely comparable. An improved visual result of 20/200 or better was achieved in 29% of patients treated with tissue adhesive as compared to 19% with other treatments.

Original languageEnglish (US)
Pages (from-to)630-635
Number of pages6
Issue number6
StatePublished - 1982
Externally publishedYes


  • corneal perforation
  • descemetocele
  • enucleation
  • tissue adhesive

ASJC Scopus subject areas

  • Ophthalmology


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