Abstract
Serum cholesterol, triglycerides and lipoprotein cholesterol were measured in cord bloods from 117 newborns. Group I consisted of 39 infants of diabetic mothers and Group II (control) consisted of 78 newborns of non-diabetic mothers. The most significant difference in serum lipids between the two groups was the higher levels of LDL cholesterol and lower levels of HDL cholesterol in the newborns of diabetic mothers. Cord blood serum cholesterol was slightly, but not significantly, higher in children born of diabetic mothers. Serum triglycerides were also not significantly different between the groups. While it remains to be established whether elevated levels of LDL cholesterol and decreased levels of HDL cholesterol at birth in these infants represent a transient phenomenon, this study suggests that newborns of diabetic mothers may be predisposed early in life to LDL hypercholesterolemia and thus may be at a greater risk of developing coronary heart disease later in life.
| Original language | English |
|---|---|
| Pages (from-to) | 263-268 |
| Number of pages | 6 |
| Journal | Journal of Chronic Diseases |
| Volume | 36 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Epidemiology
Cite this
Cord blood serum in newborns of diabetic mothers. / Fordyce, Marianna K.; Duncan, Robert; Chao, Robert; Christakis, Michael; Hsia, Sung L.; Robertson, Euan; Kafatos, Anthony; Christakis, George.
In: Journal of Chronic Diseases, Vol. 36, No. 3, 01.01.1983, p. 263-268.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Cord blood serum in newborns of diabetic mothers
AU - Fordyce, Marianna K.
AU - Duncan, Robert
AU - Chao, Robert
AU - Christakis, Michael
AU - Hsia, Sung L.
AU - Robertson, Euan
AU - Kafatos, Anthony
AU - Christakis, George
PY - 1983/1/1
Y1 - 1983/1/1
N2 - Serum cholesterol, triglycerides and lipoprotein cholesterol were measured in cord bloods from 117 newborns. Group I consisted of 39 infants of diabetic mothers and Group II (control) consisted of 78 newborns of non-diabetic mothers. The most significant difference in serum lipids between the two groups was the higher levels of LDL cholesterol and lower levels of HDL cholesterol in the newborns of diabetic mothers. Cord blood serum cholesterol was slightly, but not significantly, higher in children born of diabetic mothers. Serum triglycerides were also not significantly different between the groups. While it remains to be established whether elevated levels of LDL cholesterol and decreased levels of HDL cholesterol at birth in these infants represent a transient phenomenon, this study suggests that newborns of diabetic mothers may be predisposed early in life to LDL hypercholesterolemia and thus may be at a greater risk of developing coronary heart disease later in life.
AB - Serum cholesterol, triglycerides and lipoprotein cholesterol were measured in cord bloods from 117 newborns. Group I consisted of 39 infants of diabetic mothers and Group II (control) consisted of 78 newborns of non-diabetic mothers. The most significant difference in serum lipids between the two groups was the higher levels of LDL cholesterol and lower levels of HDL cholesterol in the newborns of diabetic mothers. Cord blood serum cholesterol was slightly, but not significantly, higher in children born of diabetic mothers. Serum triglycerides were also not significantly different between the groups. While it remains to be established whether elevated levels of LDL cholesterol and decreased levels of HDL cholesterol at birth in these infants represent a transient phenomenon, this study suggests that newborns of diabetic mothers may be predisposed early in life to LDL hypercholesterolemia and thus may be at a greater risk of developing coronary heart disease later in life.
UR - http://www.scopus.com/inward/record.url?scp=0020677748&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020677748&partnerID=8YFLogxK
U2 - 10.1016/0021-9681(83)90061-9
DO - 10.1016/0021-9681(83)90061-9
M3 - Article
C2 - 6826691
AN - SCOPUS:0020677748
VL - 36
SP - 263
EP - 268
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
SN - 0895-4356
IS - 3
ER -