Cord blood ferritin and fibroblast growth factor-23 levels in neonates

Farah N. Ali, Jami Josefson, Armando J Mendez, Karen Mestan, Myles Wolf

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Context: Elevated levels of the phosphate-regulating hormone, fibroblast growth factor-23 (FGF-23) are associated with skeletal and cardiovascular disease. Levels of FGF-23 are elevated in neonates, but the mechanisms are poorly understood. Iron deficiency is a recently described stimulus for FGF-23 production. Objective: To test the hypothesis that lower fetal iron status, as measured by lower cord blood ferritin, is independently associated with elevated FGF-23 levels in neonates. Design and Participants: This is a cross-sectional study of 64 full-term, healthy neonates. Setting: This study took place in a university-based, tertiary care center. Main Outcome Measures: Plasma levels of second generation C-terminal FGF-23 (cFGF-23) and intact FGF-23 (iFGF-23). Results: Levels of cFGF-23 ranged from 108 to 7508 reference units (RU)/ml (median, 824 RU/ml), and iFGF-23 from undetectable (<8.5) to 135.4 pg/ml (median, <8.5 pg/mL). Ferritin ranged from 58 to 719 ng/ml (mean, 203 ng/ml). Lower cord blood ferritin levels were associated with higher cFGF-23 (r = -0.320; P = .014), but not iFGF-23 levels (r = -0.222; P = .082). In multivariate analyses adjusted for glycemic indices, maternal race, and parity, lower ferritin levels remained independently associated with higher cFGF-23 levels (B = -0.261, P = .01). In the full models, higher cord blood glucose and C-peptide levels were also independently associated with higher cFGF-23 levels. Conclusions: cFGF-23, but not iFGF-23 levels, are elevated in cord blood of healthy term neonates and independently associated with lower serum ferritin and higher glycemic indices.

Original languageEnglish (US)
Pages (from-to)1673-1679
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume101
Issue number4
DOIs
StatePublished - Apr 1 2016

Fingerprint

Ferritins
Fetal Blood
Blood
Newborn Infant
Glycemic Index
Iron
C-Peptide
Parity
Tertiary Care Centers
Blood Glucose
fibroblast growth factor 23
Cardiovascular Diseases
Multivariate Analysis
Cross-Sectional Studies
Phosphates
Mothers
Outcome Assessment (Health Care)
Hormones
Plasmas
Serum

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Cord blood ferritin and fibroblast growth factor-23 levels in neonates. / Ali, Farah N.; Josefson, Jami; Mendez, Armando J; Mestan, Karen; Wolf, Myles.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 101, No. 4, 01.04.2016, p. 1673-1679.

Research output: Contribution to journalArticle

Ali, Farah N. ; Josefson, Jami ; Mendez, Armando J ; Mestan, Karen ; Wolf, Myles. / Cord blood ferritin and fibroblast growth factor-23 levels in neonates. In: Journal of Clinical Endocrinology and Metabolism. 2016 ; Vol. 101, No. 4. pp. 1673-1679.
@article{d57fe88f22c145a1a3c575c7074057ef,
title = "Cord blood ferritin and fibroblast growth factor-23 levels in neonates",
abstract = "Context: Elevated levels of the phosphate-regulating hormone, fibroblast growth factor-23 (FGF-23) are associated with skeletal and cardiovascular disease. Levels of FGF-23 are elevated in neonates, but the mechanisms are poorly understood. Iron deficiency is a recently described stimulus for FGF-23 production. Objective: To test the hypothesis that lower fetal iron status, as measured by lower cord blood ferritin, is independently associated with elevated FGF-23 levels in neonates. Design and Participants: This is a cross-sectional study of 64 full-term, healthy neonates. Setting: This study took place in a university-based, tertiary care center. Main Outcome Measures: Plasma levels of second generation C-terminal FGF-23 (cFGF-23) and intact FGF-23 (iFGF-23). Results: Levels of cFGF-23 ranged from 108 to 7508 reference units (RU)/ml (median, 824 RU/ml), and iFGF-23 from undetectable (<8.5) to 135.4 pg/ml (median, <8.5 pg/mL). Ferritin ranged from 58 to 719 ng/ml (mean, 203 ng/ml). Lower cord blood ferritin levels were associated with higher cFGF-23 (r = -0.320; P = .014), but not iFGF-23 levels (r = -0.222; P = .082). In multivariate analyses adjusted for glycemic indices, maternal race, and parity, lower ferritin levels remained independently associated with higher cFGF-23 levels (B = -0.261, P = .01). In the full models, higher cord blood glucose and C-peptide levels were also independently associated with higher cFGF-23 levels. Conclusions: cFGF-23, but not iFGF-23 levels, are elevated in cord blood of healthy term neonates and independently associated with lower serum ferritin and higher glycemic indices.",
author = "Ali, {Farah N.} and Jami Josefson and Mendez, {Armando J} and Karen Mestan and Myles Wolf",
year = "2016",
month = "4",
day = "1",
doi = "10.1210/jc.2015-3709",
language = "English (US)",
volume = "101",
pages = "1673--1679",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "4",

}

TY - JOUR

T1 - Cord blood ferritin and fibroblast growth factor-23 levels in neonates

AU - Ali, Farah N.

AU - Josefson, Jami

AU - Mendez, Armando J

AU - Mestan, Karen

AU - Wolf, Myles

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Context: Elevated levels of the phosphate-regulating hormone, fibroblast growth factor-23 (FGF-23) are associated with skeletal and cardiovascular disease. Levels of FGF-23 are elevated in neonates, but the mechanisms are poorly understood. Iron deficiency is a recently described stimulus for FGF-23 production. Objective: To test the hypothesis that lower fetal iron status, as measured by lower cord blood ferritin, is independently associated with elevated FGF-23 levels in neonates. Design and Participants: This is a cross-sectional study of 64 full-term, healthy neonates. Setting: This study took place in a university-based, tertiary care center. Main Outcome Measures: Plasma levels of second generation C-terminal FGF-23 (cFGF-23) and intact FGF-23 (iFGF-23). Results: Levels of cFGF-23 ranged from 108 to 7508 reference units (RU)/ml (median, 824 RU/ml), and iFGF-23 from undetectable (<8.5) to 135.4 pg/ml (median, <8.5 pg/mL). Ferritin ranged from 58 to 719 ng/ml (mean, 203 ng/ml). Lower cord blood ferritin levels were associated with higher cFGF-23 (r = -0.320; P = .014), but not iFGF-23 levels (r = -0.222; P = .082). In multivariate analyses adjusted for glycemic indices, maternal race, and parity, lower ferritin levels remained independently associated with higher cFGF-23 levels (B = -0.261, P = .01). In the full models, higher cord blood glucose and C-peptide levels were also independently associated with higher cFGF-23 levels. Conclusions: cFGF-23, but not iFGF-23 levels, are elevated in cord blood of healthy term neonates and independently associated with lower serum ferritin and higher glycemic indices.

AB - Context: Elevated levels of the phosphate-regulating hormone, fibroblast growth factor-23 (FGF-23) are associated with skeletal and cardiovascular disease. Levels of FGF-23 are elevated in neonates, but the mechanisms are poorly understood. Iron deficiency is a recently described stimulus for FGF-23 production. Objective: To test the hypothesis that lower fetal iron status, as measured by lower cord blood ferritin, is independently associated with elevated FGF-23 levels in neonates. Design and Participants: This is a cross-sectional study of 64 full-term, healthy neonates. Setting: This study took place in a university-based, tertiary care center. Main Outcome Measures: Plasma levels of second generation C-terminal FGF-23 (cFGF-23) and intact FGF-23 (iFGF-23). Results: Levels of cFGF-23 ranged from 108 to 7508 reference units (RU)/ml (median, 824 RU/ml), and iFGF-23 from undetectable (<8.5) to 135.4 pg/ml (median, <8.5 pg/mL). Ferritin ranged from 58 to 719 ng/ml (mean, 203 ng/ml). Lower cord blood ferritin levels were associated with higher cFGF-23 (r = -0.320; P = .014), but not iFGF-23 levels (r = -0.222; P = .082). In multivariate analyses adjusted for glycemic indices, maternal race, and parity, lower ferritin levels remained independently associated with higher cFGF-23 levels (B = -0.261, P = .01). In the full models, higher cord blood glucose and C-peptide levels were also independently associated with higher cFGF-23 levels. Conclusions: cFGF-23, but not iFGF-23 levels, are elevated in cord blood of healthy term neonates and independently associated with lower serum ferritin and higher glycemic indices.

UR - http://www.scopus.com/inward/record.url?scp=85011300266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011300266&partnerID=8YFLogxK

U2 - 10.1210/jc.2015-3709

DO - 10.1210/jc.2015-3709

M3 - Article

VL - 101

SP - 1673

EP - 1679

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 4

ER -