TY - JOUR
T1 - Cord blood ferritin and fibroblast growth factor-23 levels in neonates
AU - Ali, Farah N.
AU - Josefson, Jami
AU - Mendez, Armando J.
AU - Mestan, Karen
AU - Wolf, Myles
N1 - Funding Information:
This work was supported by grants R01DK076116 and K24DK093723 from National Institutes of Health (to M.W.) that supported the writing of the paper. Disclosure Summary: The authors have nothing to disclose.
PY - 2016/4
Y1 - 2016/4
N2 - Context: Elevated levels of the phosphate-regulating hormone, fibroblast growth factor-23 (FGF-23) are associated with skeletal and cardiovascular disease. Levels of FGF-23 are elevated in neonates, but the mechanisms are poorly understood. Iron deficiency is a recently described stimulus for FGF-23 production. Objective: To test the hypothesis that lower fetal iron status, as measured by lower cord blood ferritin, is independently associated with elevated FGF-23 levels in neonates. Design and Participants: This is a cross-sectional study of 64 full-term, healthy neonates. Setting: This study took place in a university-based, tertiary care center. Main Outcome Measures: Plasma levels of second generation C-terminal FGF-23 (cFGF-23) and intact FGF-23 (iFGF-23). Results: Levels of cFGF-23 ranged from 108 to 7508 reference units (RU)/ml (median, 824 RU/ml), and iFGF-23 from undetectable (<8.5) to 135.4 pg/ml (median, <8.5 pg/mL). Ferritin ranged from 58 to 719 ng/ml (mean, 203 ng/ml). Lower cord blood ferritin levels were associated with higher cFGF-23 (r = -0.320; P = .014), but not iFGF-23 levels (r = -0.222; P = .082). In multivariate analyses adjusted for glycemic indices, maternal race, and parity, lower ferritin levels remained independently associated with higher cFGF-23 levels (B = -0.261, P = .01). In the full models, higher cord blood glucose and C-peptide levels were also independently associated with higher cFGF-23 levels. Conclusions: cFGF-23, but not iFGF-23 levels, are elevated in cord blood of healthy term neonates and independently associated with lower serum ferritin and higher glycemic indices.
AB - Context: Elevated levels of the phosphate-regulating hormone, fibroblast growth factor-23 (FGF-23) are associated with skeletal and cardiovascular disease. Levels of FGF-23 are elevated in neonates, but the mechanisms are poorly understood. Iron deficiency is a recently described stimulus for FGF-23 production. Objective: To test the hypothesis that lower fetal iron status, as measured by lower cord blood ferritin, is independently associated with elevated FGF-23 levels in neonates. Design and Participants: This is a cross-sectional study of 64 full-term, healthy neonates. Setting: This study took place in a university-based, tertiary care center. Main Outcome Measures: Plasma levels of second generation C-terminal FGF-23 (cFGF-23) and intact FGF-23 (iFGF-23). Results: Levels of cFGF-23 ranged from 108 to 7508 reference units (RU)/ml (median, 824 RU/ml), and iFGF-23 from undetectable (<8.5) to 135.4 pg/ml (median, <8.5 pg/mL). Ferritin ranged from 58 to 719 ng/ml (mean, 203 ng/ml). Lower cord blood ferritin levels were associated with higher cFGF-23 (r = -0.320; P = .014), but not iFGF-23 levels (r = -0.222; P = .082). In multivariate analyses adjusted for glycemic indices, maternal race, and parity, lower ferritin levels remained independently associated with higher cFGF-23 levels (B = -0.261, P = .01). In the full models, higher cord blood glucose and C-peptide levels were also independently associated with higher cFGF-23 levels. Conclusions: cFGF-23, but not iFGF-23 levels, are elevated in cord blood of healthy term neonates and independently associated with lower serum ferritin and higher glycemic indices.
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U2 - 10.1210/jc.2015-3709
DO - 10.1210/jc.2015-3709
M3 - Article
C2 - 26859104
AN - SCOPUS:85011300266
VL - 101
SP - 1673
EP - 1679
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 4
ER -