Copy number variation and susceptibility to complex traits

Cesar P. Canales; Katherina Walz

doi:10.1002/emmm.201000111

Copy number variation and susceptibility to complex traits

Cesar P. Canales, Katherina Walz

Hussman Institute for Human Genomics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Copy number variations (CNV) within the genome are extremely abundant. In this closeup, Canales and Walz discuss how CNV are associated with normal variation, genomic disorders, genome evolution, adaptive traits and how the use of a novel screen described by Ermakova et al in this issue that is designed to identify human disease-relevant phenotypes associated with CNV in the mouse can help elucidating susceptibility or predisposition to diseases loci.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	EMBO Molecular Medicine
Volume	3
Issue number	1
DOIs	https://doi.org/10.1002/emmm.201000111
State	Published - Jan 2011

Keywords

CNV susceptibility
Gene dosage
Phenotypic variability

ASJC Scopus subject areas

Molecular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/emmm.201000111

Cite this

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abstract = "Copy number variations (CNV) within the genome are extremely abundant. In this closeup, Canales and Walz discuss how CNV are associated with normal variation, genomic disorders, genome evolution, adaptive traits and how the use of a novel screen described by Ermakova et al in this issue that is designed to identify human disease-relevant phenotypes associated with CNV in the mouse can help elucidating susceptibility or predisposition to diseases loci.",

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AB - Copy number variations (CNV) within the genome are extremely abundant. In this closeup, Canales and Walz discuss how CNV are associated with normal variation, genomic disorders, genome evolution, adaptive traits and how the use of a novel screen described by Ermakova et al in this issue that is designed to identify human disease-relevant phenotypes associated with CNV in the mouse can help elucidating susceptibility or predisposition to diseases loci.

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KW - Gene dosage

KW - Phenotypic variability

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Copy number variation and susceptibility to complex traits

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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