Copper-free click-chemistry platform to functionalize cisplatin prodrugs

Rakesh K. Pathak, Christopher D. McNitt, Vladimir V. Popik, Shanta Dhar

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The ability to rationally design and construct a platform technology to develop new platinum(IV) [PtIV] prodrugs with functionalities for installation of targeting moieties, delivery systems, fluorescent reporters from a single precursor with the ability to release biologically active cisplatin by using well-defined chemistry is critical for discovering new platinum-based therapeutics. With limited numbers of possibilities considering the sensitivity of PtIV centers, we used a strain-promoted azide-alkyne cycloaddition approach to provide a platform, in which new functionalities can easily be installed on cisplatin prodrugs from a single PtIV precursor. The ability of this platform to be incorporated in nanodelivery vehicle and conjugation to fluorescent reporters were also investigated.

Original languageEnglish (US)
Pages (from-to)6861-6865
Number of pages5
JournalChemistry - A European Journal
Volume20
Issue number23
DOIs
StatePublished - Jun 2 2014
Externally publishedYes

Fingerprint

Prodrugs
Platinum
Cisplatin
Copper
Alkynes
Azides
Cycloaddition

Keywords

  • cancer
  • cisplatin
  • click chemistry
  • nanoparticles
  • prodrugs

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Copper-free click-chemistry platform to functionalize cisplatin prodrugs. / Pathak, Rakesh K.; McNitt, Christopher D.; Popik, Vladimir V.; Dhar, Shanta.

In: Chemistry - A European Journal, Vol. 20, No. 23, 02.06.2014, p. 6861-6865.

Research output: Contribution to journalArticle

Pathak, Rakesh K. ; McNitt, Christopher D. ; Popik, Vladimir V. ; Dhar, Shanta. / Copper-free click-chemistry platform to functionalize cisplatin prodrugs. In: Chemistry - A European Journal. 2014 ; Vol. 20, No. 23. pp. 6861-6865.
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