Copper-free click-chemistry platform to functionalize cisplatin prodrugs

Rakesh K. Pathak, Christopher D. McNitt, Vladimir V. Popik, Shanta Dhar

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The ability to rationally design and construct a platform technology to develop new platinum(IV) [PtIV] prodrugs with functionalities for installation of targeting moieties, delivery systems, fluorescent reporters from a single precursor with the ability to release biologically active cisplatin by using well-defined chemistry is critical for discovering new platinum-based therapeutics. With limited numbers of possibilities considering the sensitivity of PtIV centers, we used a strain-promoted azide-alkyne cycloaddition approach to provide a platform, in which new functionalities can easily be installed on cisplatin prodrugs from a single PtIV precursor. The ability of this platform to be incorporated in nanodelivery vehicle and conjugation to fluorescent reporters were also investigated.

Original languageEnglish (US)
Pages (from-to)6861-6865
Number of pages5
JournalChemistry - A European Journal
Issue number23
StatePublished - Jun 2 2014
Externally publishedYes


  • cancer
  • cisplatin
  • click chemistry
  • nanoparticles
  • prodrugs

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry


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