Abstract
For the first time, p53 was found in complex with the viral large T-antigen in cells transformed with the small DNA virus SV40. p53 cDNA was cloned in the early 1980s, and the full-length p53 gene was cloned soon afterwards. The p53 family is comprised of three genes-TP53, TP63, and TP73-each of which is expressed as a set of structurally and functionally different isoforms. All of them intensely interact with each other, forming a united functional network of proteins. The review discusses the evolution of the p53 family and the significance of all its members in embryo development, reproduction, regeneration, regulation of aging and lifespan, and defense against cancer. Special attention is paid to the role of poorly studied members of the p53 family, p63 and p73, in carcinogenesis and tumor progression. Different isoforms of these proteins might exert opposite effects on these processes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 156-171 |
| Number of pages | 16 |
| Journal | Molecular Biology |
| Volume | 45 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1 2011 |
| Externally published | Yes |
Fingerprint
Keywords
- aging
- apoptosis
- carcinogenesis
- cell growth regulation
- genetic stability
- p53
- p63
- p73
- tumor suppressors
ASJC Scopus subject areas
- Biophysics
- Structural Biology
Cite this
Coordinated interaction of multifunctional members of the p53 family determines many key processes in multicellular organisms. / Vilgelm, A. E.; Zaika, Alexander; Prassolov, V. S.
In: Molecular Biology, Vol. 45, No. 1, 01.03.2011, p. 156-171.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Coordinated interaction of multifunctional members of the p53 family determines many key processes in multicellular organisms
AU - Vilgelm, A. E.
AU - Zaika, Alexander
AU - Prassolov, V. S.
PY - 2011/3/1
Y1 - 2011/3/1
N2 - For the first time, p53 was found in complex with the viral large T-antigen in cells transformed with the small DNA virus SV40. p53 cDNA was cloned in the early 1980s, and the full-length p53 gene was cloned soon afterwards. The p53 family is comprised of three genes-TP53, TP63, and TP73-each of which is expressed as a set of structurally and functionally different isoforms. All of them intensely interact with each other, forming a united functional network of proteins. The review discusses the evolution of the p53 family and the significance of all its members in embryo development, reproduction, regeneration, regulation of aging and lifespan, and defense against cancer. Special attention is paid to the role of poorly studied members of the p53 family, p63 and p73, in carcinogenesis and tumor progression. Different isoforms of these proteins might exert opposite effects on these processes.
AB - For the first time, p53 was found in complex with the viral large T-antigen in cells transformed with the small DNA virus SV40. p53 cDNA was cloned in the early 1980s, and the full-length p53 gene was cloned soon afterwards. The p53 family is comprised of three genes-TP53, TP63, and TP73-each of which is expressed as a set of structurally and functionally different isoforms. All of them intensely interact with each other, forming a united functional network of proteins. The review discusses the evolution of the p53 family and the significance of all its members in embryo development, reproduction, regeneration, regulation of aging and lifespan, and defense against cancer. Special attention is paid to the role of poorly studied members of the p53 family, p63 and p73, in carcinogenesis and tumor progression. Different isoforms of these proteins might exert opposite effects on these processes.
KW - aging
KW - apoptosis
KW - carcinogenesis
KW - cell growth regulation
KW - genetic stability
KW - p53
KW - p63
KW - p73
KW - tumor suppressors
UR - http://www.scopus.com/inward/record.url?scp=79951995824&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79951995824&partnerID=8YFLogxK
U2 - 10.1134/S002689331101016X
DO - 10.1134/S002689331101016X
M3 - Review article
AN - SCOPUS:79951995824
VL - 45
SP - 156
EP - 171
JO - Molecular Biology
JF - Molecular Biology
SN - 0026-8933
IS - 1
ER -