TY - JOUR
T1 - Conventional vs high-frequency jet ventilation in a piglet model of meconium aspiration
T2 - Comparison of pulmonary and hemodynamic effects
AU - Trindade, Oswaldo
AU - Goldberg, Ronald N.
AU - Bancalari, Eduardo
AU - Dickstein, Paulo
AU - Ellison, Jan
AU - Gerhardt, Tilo
N1 - Funding Information:
From the Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine. Supported in part by Grants 1 ROI HD14940-03 and 5 ROI HL25023-O3 from the National Institutes of Health, by the State of Florida, Department of Health and Rehabilitative Services, Children's Medical Services, and by the University of Miami, Project Newborn. Submitted for publication June 11, 1984; accepted Dec. 13, 1984. Reprint requests: Ronald N. Goldberg, M.D., Department of Pediatrics (R-131), University of Miami School of Medicine, P.O. Box 016960, Miami, FL 33101.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1985/7
Y1 - 1985/7
N2 - The pulmonary and cardiovascular effects of high-frequency jet (HFJV) and conventional (CV) ventilation were evaluated in a piglet model of meconium aspiration. A mixture of 20% human meconium and 0.9% saline solution was instilled deep into the trachea of 10 piglets, after which either HFJV or CV was administered for 4 hours. Arterial blood gases, cardiac output, mean pulmonary and systemic arterial pressures, pulmonary and systemic vascular resistances, and pulmonary mechanics were compared between groups. During the 4 hours of ventilation, Pao2 and Paco2 were not statistically different between groups. The peak inśpiratory pressure necessary to maintain Paco2 in the preset range was approximately half as much in the HFJV group as in the CV group (P<0.002). Mean airway pressure was lower in the HFJV group only during the second hour (P<0.03). Cardiac output, mean aortic and pulmonary artery pressures, systemic and pulmonary vascular resistance, dynamic lung compliance, and pulmonary resistance were not statistically different between groups. Our results suggest that HFJV may be more effective than CV in the early stages of meconium aspiration syndrome because HFJV allows more efficient ventilation and adequate oxygenation at lower peak inspiratory pressures.
AB - The pulmonary and cardiovascular effects of high-frequency jet (HFJV) and conventional (CV) ventilation were evaluated in a piglet model of meconium aspiration. A mixture of 20% human meconium and 0.9% saline solution was instilled deep into the trachea of 10 piglets, after which either HFJV or CV was administered for 4 hours. Arterial blood gases, cardiac output, mean pulmonary and systemic arterial pressures, pulmonary and systemic vascular resistances, and pulmonary mechanics were compared between groups. During the 4 hours of ventilation, Pao2 and Paco2 were not statistically different between groups. The peak inśpiratory pressure necessary to maintain Paco2 in the preset range was approximately half as much in the HFJV group as in the CV group (P<0.002). Mean airway pressure was lower in the HFJV group only during the second hour (P<0.03). Cardiac output, mean aortic and pulmonary artery pressures, systemic and pulmonary vascular resistance, dynamic lung compliance, and pulmonary resistance were not statistically different between groups. Our results suggest that HFJV may be more effective than CV in the early stages of meconium aspiration syndrome because HFJV allows more efficient ventilation and adequate oxygenation at lower peak inspiratory pressures.
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U2 - 10.1016/S0022-3476(85)80631-4
DO - 10.1016/S0022-3476(85)80631-4
M3 - Article
C2 - 3891945
AN - SCOPUS:0021806569
VL - 107
SP - 115
EP - 120
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 1
ER -