Controversies in topical antibiotics use with intravitreal injections

Stephen G. Schwartz, Harry W. Flynn, Andrzej Grzybowski

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Endophthalmitis following intravitreal injection is uncommon. There are currently no randomized clinical trials evaluating the role of prophylactic topical antibiotics in this setting. Many large series have reported that topical antibiotics do not decrease, and may in fact increase the rate of endophthalmitis. The reason for this apparent paradoxical finding is unknown but may be due to changes in conjunctival flora due to repeated exposure to antibiotics. At this time, antiseptics (specifically povidone-iodine), rather than antibiotics, are preferred for the majority of patients undergoing intravitreal injections.

Original languageEnglish (US)
Pages (from-to)4703-4706
Number of pages4
JournalCurrent pharmaceutical design
Issue number32
StatePublished - Oct 1 2015


  • Endophthalmitis
  • Intravitreal injections
  • Randomized clinical trials
  • Topical antibiotics
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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