TY - JOUR
T1 - Controlling exit site infections
T2 - Does it decrease the incidence of catheter-related bacteremia in children on chronic hemodialysis?
AU - Onder, Ali Mirza
AU - Chandar, Jayanthi
AU - Coakley, Sheila
AU - Francoeur, Denise
AU - Abitbol, Carolyn
AU - Zilleruelo, Gaston
PY - 2009/2/6
Y1 - 2009/2/6
N2 - The aim of this retrospective study was to investigate whether the application of a chlorhexidine-impregnated dressing (Biopatch®) at the exit site of tunneled-cuffed hemodialysis catheters has any effect on the incidence and etiology of catheter-related bacteremia (CRB). This study was carried out over a 5-year period in a single center, where, in the first 21/2; years, the exit sites were cleansed with betadine at every hemodialysis session and then covered with a transparent dressing (pre-Biopatch® Era). During the next 21/2; years, Biopatch® was applied to the exit site once a week after cleansing with betadine, and then covered with a transparent dressing (Biopatch® Era). The application of Biopatch® significantly decreased the incidence of exit site infections (ESI) (P < 0.05). However, there was no difference in the incidence of CRBs or their microbiological distribution. The improved ESI rate had no effect on the overall catheter survival time. The antimicrobial sensitivities of the Gram-positive microorganisms were statistically different for the 2 different types of infections (P < 0.05). In conclusion, even though Biopatch® is effective in decreasing the incidence of ESI, it has no effect on the incidence of CRB, the etiology of CRB, or the overall catheter survival time. The distinct difference between the antimicrobial sensitivities of the ESI and CRB suggests that they are not a spectrum of the same pathogenesis. These preliminary data support the intraluminal pathogenesis of CRB, rather than the exit site as a possible entry point for the extraluminal route.
AB - The aim of this retrospective study was to investigate whether the application of a chlorhexidine-impregnated dressing (Biopatch®) at the exit site of tunneled-cuffed hemodialysis catheters has any effect on the incidence and etiology of catheter-related bacteremia (CRB). This study was carried out over a 5-year period in a single center, where, in the first 21/2; years, the exit sites were cleansed with betadine at every hemodialysis session and then covered with a transparent dressing (pre-Biopatch® Era). During the next 21/2; years, Biopatch® was applied to the exit site once a week after cleansing with betadine, and then covered with a transparent dressing (Biopatch® Era). The application of Biopatch® significantly decreased the incidence of exit site infections (ESI) (P < 0.05). However, there was no difference in the incidence of CRBs or their microbiological distribution. The improved ESI rate had no effect on the overall catheter survival time. The antimicrobial sensitivities of the Gram-positive microorganisms were statistically different for the 2 different types of infections (P < 0.05). In conclusion, even though Biopatch® is effective in decreasing the incidence of ESI, it has no effect on the incidence of CRB, the etiology of CRB, or the overall catheter survival time. The distinct difference between the antimicrobial sensitivities of the ESI and CRB suggests that they are not a spectrum of the same pathogenesis. These preliminary data support the intraluminal pathogenesis of CRB, rather than the exit site as a possible entry point for the extraluminal route.
KW - Betadine
KW - Biopatch®
KW - Catheter survival
KW - Catheter-related bacteremia
KW - Chlorhexidine
KW - Exit site infection
KW - Sepsis
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UR - http://www.scopus.com/inward/citedby.url?scp=59249108813&partnerID=8YFLogxK
U2 - 10.1111/j.1542-4758.2009.00348.x
DO - 10.1111/j.1542-4758.2009.00348.x
M3 - Article
C2 - 19210272
AN - SCOPUS:59249108813
VL - 13
SP - 11
EP - 18
JO - Hemodialysis International
JF - Hemodialysis International
SN - 1492-7535
IS - 1
ER -