Controlled Release Strategies in Tissue Engineering

Jeffrey Hubbell

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

This chapter deals with the tissue-engineering strategies that depend heavily on the provision of bioactive signals, be they substrate-bound adhesion signals, or bound or diffusible growth factor signals. As such, controlled release technologies play an important role in the overall task of tissue engineering. Controlled release means that the drug is released from the surface or bulk of an implant slowly over long periods of time, and sometimes it means that the drug is immobilized on the surface of or throughout the material and is not released at all. The difference depends on the mode of action of the drug. In tissue engineering, one often uses biomaterial scaffolds or matrices, here using the word scaffold to refer to a macro- or microporous material used to provide a structural support and the word matrix to refer to a nanoporous continuous material for the same purpose.

Original languageEnglish
Title of host publicationTissue Engineering
PublisherElsevier Inc.
Pages455-482
Number of pages28
ISBN (Print)9780123708694
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

Fingerprint

Tissue engineering
Microporous materials
Scaffolds (biology)
Biomaterials
Scaffolds
Macros
Adhesion
Substrates

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Hubbell, J. (2008). Controlled Release Strategies in Tissue Engineering. In Tissue Engineering (pp. 455-482). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-370869-4.00015-X

Controlled Release Strategies in Tissue Engineering. / Hubbell, Jeffrey.

Tissue Engineering. Elsevier Inc., 2008. p. 455-482.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hubbell, J 2008, Controlled Release Strategies in Tissue Engineering. in Tissue Engineering. Elsevier Inc., pp. 455-482. https://doi.org/10.1016/B978-0-12-370869-4.00015-X
Hubbell, Jeffrey. / Controlled Release Strategies in Tissue Engineering. Tissue Engineering. Elsevier Inc., 2008. pp. 455-482
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