Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses

André Mercanzini, Sai T. Reddy, Diana Velluto, Philippe Colin, Anne Maillard, Jean Charles Bensadoun, Jeffrey A. Hubbell, Philippe Renaud

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Controlled release coatings were developed for neuroprostheses with the aim of combating the tissue reaction following implantation in the brain. The coatings consist of poly(propylene sulfide) drug-eluting nanoparticles embedded in a poly(ethylene oxide) matrix. The nanoparticles are loaded with dexamethasone, an anti-inflammatory drug known to have an effect on the cells activated during the damage caused by implantation. The nanoparticles are not affected by the coating process and the drug remains bioactive after it is released. The coating was applied to microfabricated cortical neuroprostheses consisting of platinum and polyimide. Coated drug-eluting devices were implanted in the cortex of rats. After implantation the matrix dissolves, exposing the electrode surfaces, while the nanoparticles remain in the vicinity of the tissue-implant interface. Using electrical impedance spectroscopy and comparative histology, a long-term decrease in the tissue response in comparison to control devices was observed. These coatings can therefore be used to increase the reliability and long-term efficacy of neuroprostheses.

Original languageEnglish
Pages (from-to)196-202
Number of pages7
JournalJournal of Controlled Release
Volume145
Issue number3
DOIs
StatePublished - Aug 1 2010
Externally publishedYes

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Keywords

  • Microfabrication
  • Nanoparticles
  • Neuroprosthesis

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Mercanzini, A., Reddy, S. T., Velluto, D., Colin, P., Maillard, A., Bensadoun, J. C., Hubbell, J. A., & Renaud, P. (2010). Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses. Journal of Controlled Release, 145(3), 196-202. https://doi.org/10.1016/j.jconrel.2010.04.025