Controlled release drug coatings on flexible neural probes

André Mercanzini, Sai Reddy, Diana Velluto, Philippe Colin, Anne Maillard, Jean Charles Bensadoun, Arnaud Bertsch, Jeffrey A. Hubbell, Philippe Renaud

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

We present the development, characterization and in vivo validation of a novel drug eluting coating that has been applied to flexible neural probes. The coating consists of drug eluting nanoparticles loaded with an anti-inflammatory drug embedded in a biodegradable polymer. The drug eluting coating is applied to flexible polymer neural probes with platinum electrodes. The drug eluting device is implanted in one hemisphere of a rat, while a control device is implanted in the opposite hemisphere. Impedance measurements are performed to determine the effect of the drug eluting coating on the tissue reaction surrounding the probe and the electrical characteristics of the devices. Probes that are coated with drug eluting coatings show better long term impedance characteristics over control probes. These coatings can be used to increase the reliability and long term success of neural prostheses.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages6612-6615
Number of pages4
DOIs
StatePublished - Dec 1 2007
Externally publishedYes
Event29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07 - Lyon, France
Duration: Aug 23 2007Aug 26 2007

Other

Other29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
CountryFrance
CityLyon
Period8/23/078/26/07

Fingerprint

Coatings
Neural prostheses
Biodegradable polymers
Rats
Platinum
Tissue
Nanoparticles
Electrodes
Polymers

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Mercanzini, A., Reddy, S., Velluto, D., Colin, P., Maillard, A., Bensadoun, J. C., ... Renaud, P. (2007). Controlled release drug coatings on flexible neural probes. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (pp. 6612-6615). [4353875] https://doi.org/10.1109/IEMBS.2007.4353875

Controlled release drug coatings on flexible neural probes. / Mercanzini, André; Reddy, Sai; Velluto, Diana; Colin, Philippe; Maillard, Anne; Bensadoun, Jean Charles; Bertsch, Arnaud; Hubbell, Jeffrey A.; Renaud, Philippe.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2007. p. 6612-6615 4353875.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mercanzini, A, Reddy, S, Velluto, D, Colin, P, Maillard, A, Bensadoun, JC, Bertsch, A, Hubbell, JA & Renaud, P 2007, Controlled release drug coatings on flexible neural probes. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings., 4353875, pp. 6612-6615, 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07, Lyon, France, 8/23/07. https://doi.org/10.1109/IEMBS.2007.4353875
Mercanzini A, Reddy S, Velluto D, Colin P, Maillard A, Bensadoun JC et al. Controlled release drug coatings on flexible neural probes. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2007. p. 6612-6615. 4353875 https://doi.org/10.1109/IEMBS.2007.4353875
Mercanzini, André ; Reddy, Sai ; Velluto, Diana ; Colin, Philippe ; Maillard, Anne ; Bensadoun, Jean Charles ; Bertsch, Arnaud ; Hubbell, Jeffrey A. ; Renaud, Philippe. / Controlled release drug coatings on flexible neural probes. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2007. pp. 6612-6615
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