@article{8d9c58da27934334aecf0fdb31df1906,
title = "Controlled Nutrient Delivery to Pancreatic Islets Using Polydopamine-Coated Mesoporous Silica Nanoparticles",
abstract = "In the present study, we created a nanoscale platform that can deliver nutrients to pancreatic islets in a controlled manner. Our platform consists of a mesoporous silica nanoparticle (MSNP), which can be loaded with glutamine (G: an essential amino acid required for islet survival and function). To control the release of G, MSNPs were coated with a polydopamine (PD) layer. With the optimal parameters (0.5 mg/mL and 0.5 h), MSNPs were coated with a layer of PD, which resulted in a delay of G release from MSNPs over 14 d (57.4 ± 4.7% release). Following syngeneic renal subcapsule islet transplantation in diabetic mice, PDG-MSNPs improved the engraftment of islets (i.e., enhanced revascularization and reduced inflammation) as well as their function, resulting in re-establishment of glycemic control. Collectively, our data show that PDG-MSNPs can support transplanted islets by providing them with a controlled and sustained supply of nutrients.",
keywords = "Diabetes, Glutamine, Islet transplantation, Mesoporous silica nanoparticles, Nutrient delivery, Polydopamine",
author = "Mehdi Razavi and Rosita Primavera and Kevadiya, {Bhavesh D.} and Jing Wang and Mujib Ullah and Peter Buchwald and Thakor, {Avnesh S.}",
note = "Funding Information: This work was supported by research grants from the NIDDK (R01DK119293 and P30DK116074), the Stanford Nano Shared Facilities grant (1161726-146-DAARZ), as part of the grant supported by the National Science Foundation grant (ECCS-1542152) and Stanford Neuroscience Microscopy Service grant (NIH NS069375) as well as the Akiko Yamazaki and Jerry Yang Faculty Scholar Fund in Pediatric Translational Medicine, and the Stanford Maternal and Child Health Research Institute. The authors thank Research Professor Y. J. Zhou, PhD. Director of Morrison Microscopy Core Research Facility, Center for Biotechnology University of Nebraska-Lincoln for the technical support related to the TEM data. The authors also acknowledge A. Thomas for her help on preparing the TOC graphic. Funding Information: This work was supported by research grants from the NIDDK (R01DK119293 and P30DK116074), the Stanford Nano Shared Facilities grant (1161726-146-DAARZ), as part of the grant supported by the National Science Foundation grant (ECCS-1542152) and Stanford Neuroscience Microscopy Service grant (NIH NS069375) as well as the Akiko Yamazaki and Jerry Yang Faculty Scholar Fund in Pediatric Translational Medicine, and the Stanford Maternal and Child Health Research Institute. The authors thank Research Professor Y. J. Zhou, PhD. Director of Morrison Microscopy Core Research Facility, Center for Biotechnology, University of Nebraska-Lincoln for the technical support related to the TEM data. The authors also acknowledge A. Thomas for her help on preparing the TOC graphic. Publisher Copyright: Copyright {\textcopyright} 2020 American Chemical Society.",
year = "2020",
month = oct,
day = "14",
doi = "10.1021/acs.nanolett.0c02576",
language = "English (US)",
volume = "20",
pages = "7220--7229",
journal = "Nano Letters",
issn = "1530-6984",
publisher = "American Chemical Society",
number = "10",
}