Controlled Nutrient Delivery to Pancreatic Islets Using Polydopamine-Coated Mesoporous Silica Nanoparticles

Mehdi Razavi, Rosita Primavera, Bhavesh D. Kevadiya, Jing Wang, Mujib Ullah, Peter Buchwald, Avnesh S. Thakor

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

In the present study, we created a nanoscale platform that can deliver nutrients to pancreatic islets in a controlled manner. Our platform consists of a mesoporous silica nanoparticle (MSNP), which can be loaded with glutamine (G: an essential amino acid required for islet survival and function). To control the release of G, MSNPs were coated with a polydopamine (PD) layer. With the optimal parameters (0.5 mg/mL and 0.5 h), MSNPs were coated with a layer of PD, which resulted in a delay of G release from MSNPs over 14 d (57.4 ± 4.7% release). Following syngeneic renal subcapsule islet transplantation in diabetic mice, PDG-MSNPs improved the engraftment of islets (i.e., enhanced revascularization and reduced inflammation) as well as their function, resulting in re-establishment of glycemic control. Collectively, our data show that PDG-MSNPs can support transplanted islets by providing them with a controlled and sustained supply of nutrients.

Original languageEnglish (US)
Pages (from-to)7220-7229
Number of pages10
JournalNano Letters
Volume20
Issue number10
DOIs
StatePublished - Oct 14 2020

Keywords

  • Diabetes
  • Glutamine
  • Islet transplantation
  • Mesoporous silica nanoparticles
  • Nutrient delivery
  • Polydopamine

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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