Abstract
In order to study the role of CO2 and acid-base status in contributing to ventilatory drive, skate were exposed to normoxic hypercapnia (PICO2 = 7.5 Torr) under conditions where the primary O2 drive a small Bohr effect. Red blood cell pHi was not preferentially regulated, and there was no evidence of RBC swelling or nucleoside triphosphate adjustment. Although there were no changes in arterial O2 levels during hypercapnia, ventilation immediately increased 2.7-fold through large changes in stroke volume and small changes in frequency, and declined only slightly through 24-48 h. PaCO2 equilibrated rapidly with PICO2, driving down arterial pHa, which was 65% corrected through HCO3- accumulation by 24 h. In contrast, the extradural fluid outside the brain equilibrated only very slowly, and was clearly not involved in the ventilatory stimulation. Increased ventilation during hypercapnia may be related to depressions in pHa.
| Original language | English |
|---|---|
| Pages (from-to) | 259-277 |
| Number of pages | 19 |
| Journal | Respiration Physiology |
| Volume | 80 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Jan 1 1990 |
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Keywords
- Animal, skate
- Blood, O transport properties in skate
- Bohr effect in skate
- Cerebrospinal fluid, acid-base balance
- Control of breathing, cerebrospinal fluid in skate, response to CO
- Hypercapnia, ventilatory response in skate
- pH, intracellular
- Red cell, intracellular pH in skate
- Ventilation, sensitivity to CO in skate
ASJC Scopus subject areas
- Physiology
- Pulmonary and Respiratory Medicine
Cite this
Control of ventilation in the hypercapnic skate Raja ocellata : I. Blood and extradural fluid. / Graham, M. S.; Turner, J. D.; Wood, C. M.
In: Respiration Physiology, Vol. 80, No. 2-3, 01.01.1990, p. 259-277.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Control of ventilation in the hypercapnic skate Raja ocellata
T2 - I. Blood and extradural fluid
AU - Graham, M. S.
AU - Turner, J. D.
AU - Wood, C. M.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - In order to study the role of CO2 and acid-base status in contributing to ventilatory drive, skate were exposed to normoxic hypercapnia (PICO2 = 7.5 Torr) under conditions where the primary O2 drive a small Bohr effect. Red blood cell pHi was not preferentially regulated, and there was no evidence of RBC swelling or nucleoside triphosphate adjustment. Although there were no changes in arterial O2 levels during hypercapnia, ventilation immediately increased 2.7-fold through large changes in stroke volume and small changes in frequency, and declined only slightly through 24-48 h. PaCO2 equilibrated rapidly with PICO2, driving down arterial pHa, which was 65% corrected through HCO3- accumulation by 24 h. In contrast, the extradural fluid outside the brain equilibrated only very slowly, and was clearly not involved in the ventilatory stimulation. Increased ventilation during hypercapnia may be related to depressions in pHa.
AB - In order to study the role of CO2 and acid-base status in contributing to ventilatory drive, skate were exposed to normoxic hypercapnia (PICO2 = 7.5 Torr) under conditions where the primary O2 drive a small Bohr effect. Red blood cell pHi was not preferentially regulated, and there was no evidence of RBC swelling or nucleoside triphosphate adjustment. Although there were no changes in arterial O2 levels during hypercapnia, ventilation immediately increased 2.7-fold through large changes in stroke volume and small changes in frequency, and declined only slightly through 24-48 h. PaCO2 equilibrated rapidly with PICO2, driving down arterial pHa, which was 65% corrected through HCO3- accumulation by 24 h. In contrast, the extradural fluid outside the brain equilibrated only very slowly, and was clearly not involved in the ventilatory stimulation. Increased ventilation during hypercapnia may be related to depressions in pHa.
KW - Animal, skate
KW - Blood, O transport properties in skate
KW - Bohr effect in skate
KW - Cerebrospinal fluid, acid-base balance
KW - Control of breathing, cerebrospinal fluid in skate, response to CO
KW - Hypercapnia, ventilatory response in skate
KW - pH, intracellular
KW - Red cell, intracellular pH in skate
KW - Ventilation, sensitivity to CO in skate
UR - http://www.scopus.com/inward/record.url?scp=0025362669&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025362669&partnerID=8YFLogxK
U2 - 10.1016/0034-5687(90)90088-G
DO - 10.1016/0034-5687(90)90088-G
M3 - Article
C2 - 2120753
AN - SCOPUS:0025362669
VL - 80
SP - 259
EP - 277
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
IS - 2-3
ER -