Control of ventilation in the hypercapnic skate Raja ocellata: I. Blood and extradural fluid

M. S. Graham; J. D. Turner; C. M. Wood

doi:10.1016/0034-5687(90)90088-G

Control of ventilation in the hypercapnic skate Raja ocellata: I. Blood and extradural fluid

M. S. Graham, J. D. Turner, C. M. Wood

Marine Biology and Fisheries

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

In order to study the role of CO₂ and acid-base status in contributing to ventilatory drive, skate were exposed to normoxic hypercapnia (PI_CO₂ = 7.5 Torr) under conditions where the primary O₂ drive a small Bohr effect. Red blood cell pHi was not preferentially regulated, and there was no evidence of RBC swelling or nucleoside triphosphate adjustment. Although there were no changes in arterial O₂ levels during hypercapnia, ventilation immediately increased 2.7-fold through large changes in stroke volume and small changes in frequency, and declined only slightly through 24-48 h. Pa_CO₂ equilibrated rapidly with PI_CO₂, driving down arterial pHa, which was 65% corrected through HCO₃^- accumulation by 24 h. In contrast, the extradural fluid outside the brain equilibrated only very slowly, and was clearly not involved in the ventilatory stimulation. Increased ventilation during hypercapnia may be related to depressions in pHa.

Original language	English (US)
Pages (from-to)	259-277
Number of pages	19
Journal	Respiration Physiology
Volume	80
Issue number	2-3
DOIs	https://doi.org/10.1016/0034-5687(90)90088-G
State	Published - Jan 1 1990

Keywords

Animal, skate
Blood, O transport properties in skate
Bohr effect in skate
Cerebrospinal fluid, acid-base balance
Control of breathing, cerebrospinal fluid in skate, response to CO
Hypercapnia, ventilatory response in skate
pH, intracellular
Red cell, intracellular pH in skate
Ventilation, sensitivity to CO in skate

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine

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10.1016/0034-5687(90)90088-G

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title = "Control of ventilation in the hypercapnic skate Raja ocellata: I. Blood and extradural fluid",

abstract = "In order to study the role of CO2 and acid-base status in contributing to ventilatory drive, skate were exposed to normoxic hypercapnia (PICO2 = 7.5 Torr) under conditions where the primary O2 drive a small Bohr effect. Red blood cell pHi was not preferentially regulated, and there was no evidence of RBC swelling or nucleoside triphosphate adjustment. Although there were no changes in arterial O2 levels during hypercapnia, ventilation immediately increased 2.7-fold through large changes in stroke volume and small changes in frequency, and declined only slightly through 24-48 h. PaCO2 equilibrated rapidly with PICO2, driving down arterial pHa, which was 65% corrected through HCO3- accumulation by 24 h. In contrast, the extradural fluid outside the brain equilibrated only very slowly, and was clearly not involved in the ventilatory stimulation. Increased ventilation during hypercapnia may be related to depressions in pHa.",

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N2 - In order to study the role of CO2 and acid-base status in contributing to ventilatory drive, skate were exposed to normoxic hypercapnia (PICO2 = 7.5 Torr) under conditions where the primary O2 drive a small Bohr effect. Red blood cell pHi was not preferentially regulated, and there was no evidence of RBC swelling or nucleoside triphosphate adjustment. Although there were no changes in arterial O2 levels during hypercapnia, ventilation immediately increased 2.7-fold through large changes in stroke volume and small changes in frequency, and declined only slightly through 24-48 h. PaCO2 equilibrated rapidly with PICO2, driving down arterial pHa, which was 65% corrected through HCO3- accumulation by 24 h. In contrast, the extradural fluid outside the brain equilibrated only very slowly, and was clearly not involved in the ventilatory stimulation. Increased ventilation during hypercapnia may be related to depressions in pHa.

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