Control of T cell development in vivo by subdomains within the IL-7 receptor α-chain cytoplasmic tail

B. O. Porter, P. Scibelli, T. R. Malek

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

IL-7/IL-7R signaling functions in both growth and differentiation during T cell development. In this study, we examined the extent these activities were controlled by signaling associated with distinct IL-7Rα cytoplasmic domains by transgenic expression of wild-type or cytoplasmic deletion mutants of IL-7Rα in the thymi of IL-7Rα-/- mice. We show an essential requirement for the tyrosine-containing carboxyl-terminal T domain in restoring thymic cellularity, pro-/pre-T cell progression, and survival. In contrast, the functional differentiation of TCR αβ cells and the development of TCR γδ cells are partially independent of the T domain. Thus, separate cytoplasmic domains of the IL-7Rα chain differentially control distinct functions during T cell development, whereas normal IL-7R-dependent thymic development requires the integrated activity of all these domains.

Original languageEnglish (US)
Pages (from-to)262-269
Number of pages8
JournalJournal of Immunology
Volume166
Issue number1
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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