Control of inflammatory processes by cell-impermeable inhibitors of phospholipase A2

S. Yedgar, P. Dan, A. Dagan, I. Ginsburg, I. S. Lossos, R. Breuer

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Cell-impermeable inhibitors of phospholipase A2 were prepared by linking inhibiting molecules to macromolecular carriers which prevent the inhibitor's internalization. These preparations inhibit the release of oxygen reactive species from neutrophils and cell death induced by inflammatory agents, as well as bleomycin-induced lung injury.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalAgents and Actions
Volume46
Issue numberSUPPL.
DOIs
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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