Control of immunity in parental and F1, hybrid mouse strains to a spontaneously arising parental tumor I. Correlation between in vitro and in vivo anti‐tumor reactivity in responsive and unresponsive animals

R. B. Levy, S. D. Waksal, Gene M. Shearer

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This study investigated the in vivo and in vitro cellular immunity of the AKR/J, (AKR/J x C57BL/6)F1 and (AKR/J x DBA/2)F1 mouse strains to a spontaneously arising AKR/J tumor. It is concluded that: there is an excellent correlation between the growth of the tumor in vivo, and the ability of spleen cells from the respective strains to generate both primary and secondary cell-mediated cytotoxic responses in vitro; and one F1 host can be considered a responder against this tumor, whereas the other F1 strain studied appears to be genetically nonresponsive. Possible mechanisms relating to the observed patterns of response are discussed.

Original languageEnglish (US)
Pages (from-to)170-174
Number of pages5
JournalEuropean Journal of Immunology
Issue number3
StatePublished - Mar 1977
Externally publishedYes


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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