This study investigated the in vivo and in vitro cellular immunity of the AKR/J, (AKR/J x C57BL/6)F1 and (AKR/J x DBA/2)F1 mouse strains to a spontaneously arising AKR/J tumor. It is concluded that: there is an excellent correlation between the growth of the tumor in vivo, and the ability of spleen cells from the respective strains to generate both primary and secondary cell-mediated cytotoxic responses in vitro; and one F1 host can be considered a responder against this tumor, whereas the other F1 strain studied appears to be genetically nonresponsive. Possible mechanisms relating to the observed patterns of response are discussed.
ASJC Scopus subject areas
- Immunology and Allergy