Control of immunity in parental and F1 hybrid mouse strains to a spontaneously arising parental tumor. I. Correlation between in vitro and in vivo anti tumor reactivity in responsive and unresponsive animals

Robert B Levy, S. D. Waksal, G. M. Shearer

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Abstract

This study investigated the in vivo and in vitro cellular immunity of the AKR/J, (AKR/J x C57BL/6)F1 and (AKR/J x DBA/2)F1 mouse strains to a spontaneously arising AKR/J tumor. It is concluded that: there is an excellent correlation between the growth of the tumor in vivo, and the ability of spleen cells from the respective strains to generate both primary and secondary cell-mediated cytotoxic responses in vitro; and one F1 host can be considered a responder against this tumor, whereas the other F1 strain studied appears to be genetically nonresponsive. Possible mechanisms relating to the observed patterns of response are discussed.

Original languageEnglish
Pages (from-to)170-174
Number of pages5
JournalEuropean Journal of Immunology
Volume7
Issue number3
StatePublished - Jan 1 1977
Externally publishedYes

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Immunity
Neoplasms
Cellular Immunity
Spleen
Growth
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology

Cite this

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title = "Control of immunity in parental and F1 hybrid mouse strains to a spontaneously arising parental tumor. I. Correlation between in vitro and in vivo anti tumor reactivity in responsive and unresponsive animals",
abstract = "This study investigated the in vivo and in vitro cellular immunity of the AKR/J, (AKR/J x C57BL/6)F1 and (AKR/J x DBA/2)F1 mouse strains to a spontaneously arising AKR/J tumor. It is concluded that: there is an excellent correlation between the growth of the tumor in vivo, and the ability of spleen cells from the respective strains to generate both primary and secondary cell-mediated cytotoxic responses in vitro; and one F1 host can be considered a responder against this tumor, whereas the other F1 strain studied appears to be genetically nonresponsive. Possible mechanisms relating to the observed patterns of response are discussed.",
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T1 - Control of immunity in parental and F1 hybrid mouse strains to a spontaneously arising parental tumor. I. Correlation between in vitro and in vivo anti tumor reactivity in responsive and unresponsive animals

AU - Levy, Robert B

AU - Waksal, S. D.

AU - Shearer, G. M.

PY - 1977/1/1

Y1 - 1977/1/1

N2 - This study investigated the in vivo and in vitro cellular immunity of the AKR/J, (AKR/J x C57BL/6)F1 and (AKR/J x DBA/2)F1 mouse strains to a spontaneously arising AKR/J tumor. It is concluded that: there is an excellent correlation between the growth of the tumor in vivo, and the ability of spleen cells from the respective strains to generate both primary and secondary cell-mediated cytotoxic responses in vitro; and one F1 host can be considered a responder against this tumor, whereas the other F1 strain studied appears to be genetically nonresponsive. Possible mechanisms relating to the observed patterns of response are discussed.

AB - This study investigated the in vivo and in vitro cellular immunity of the AKR/J, (AKR/J x C57BL/6)F1 and (AKR/J x DBA/2)F1 mouse strains to a spontaneously arising AKR/J tumor. It is concluded that: there is an excellent correlation between the growth of the tumor in vivo, and the ability of spleen cells from the respective strains to generate both primary and secondary cell-mediated cytotoxic responses in vitro; and one F1 host can be considered a responder against this tumor, whereas the other F1 strain studied appears to be genetically nonresponsive. Possible mechanisms relating to the observed patterns of response are discussed.

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EP - 174

JO - European Journal of Immunology

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