Control of hypertension with the angiotensin converting enzyme inhibitor captopril reduces glomerular proteinuria

L. M. Ruilope, B. Miranda, A. Oliet, V. G. Millet, J. L. Rodicio, J. C. Romero, Leopoldo Raij

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Recent experimental and clinical data have suggested that angiotension converting enzyme (ACE) inhibitors may decrease glomerular proteinuria by specific effects on the glomerulus. We studied a group of 15 adult patients with chronic renal failure and proteinuria due to various glomerulopathies. These patients had mild to moderate hypertension which was effectively controlled with conventional antihypertensive therapy. We then treated the patients with captopril, maintaining a similar dietary protein and salt intake. After 6 months of study, proteinuria was reduced significantly without reduction in inulin or para-aminohipurrate clearance. This supports the concept that captopril may have salutary effects on the glomerulus, independently of its effect on systemic blood pressure.

Original languageEnglish
JournalJournal of Hypertension
Volume6
Issue numberSUPPL. 4
StatePublished - Dec 1 1988
Externally publishedYes

Fingerprint

Captopril
Proteinuria
Angiotensin-Converting Enzyme Inhibitors
Hypertension
Inulin
Dietary Proteins
Enzyme Inhibitors
Antihypertensive Agents
Chronic Kidney Failure
Salts
Blood Pressure
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine

Cite this

Ruilope, L. M., Miranda, B., Oliet, A., Millet, V. G., Rodicio, J. L., Romero, J. C., & Raij, L. (1988). Control of hypertension with the angiotensin converting enzyme inhibitor captopril reduces glomerular proteinuria. Journal of Hypertension, 6(SUPPL. 4).

Control of hypertension with the angiotensin converting enzyme inhibitor captopril reduces glomerular proteinuria. / Ruilope, L. M.; Miranda, B.; Oliet, A.; Millet, V. G.; Rodicio, J. L.; Romero, J. C.; Raij, Leopoldo.

In: Journal of Hypertension, Vol. 6, No. SUPPL. 4, 01.12.1988.

Research output: Contribution to journalArticle

Ruilope, LM, Miranda, B, Oliet, A, Millet, VG, Rodicio, JL, Romero, JC & Raij, L 1988, 'Control of hypertension with the angiotensin converting enzyme inhibitor captopril reduces glomerular proteinuria', Journal of Hypertension, vol. 6, no. SUPPL. 4.
Ruilope LM, Miranda B, Oliet A, Millet VG, Rodicio JL, Romero JC et al. Control of hypertension with the angiotensin converting enzyme inhibitor captopril reduces glomerular proteinuria. Journal of Hypertension. 1988 Dec 1;6(SUPPL. 4).
Ruilope, L. M. ; Miranda, B. ; Oliet, A. ; Millet, V. G. ; Rodicio, J. L. ; Romero, J. C. ; Raij, Leopoldo. / Control of hypertension with the angiotensin converting enzyme inhibitor captopril reduces glomerular proteinuria. In: Journal of Hypertension. 1988 ; Vol. 6, No. SUPPL. 4.
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