Control of hypertension with the angiotensin converting enzyme inhibitor captopril reduces glomerular proteinuria

Luis M. Ruilope, Blanca Miranda, Aniana Oliet, Victor G. Millet, Jose L. Rodicio, J. Carlos Romero, Leopoldo Raij

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Recent experimental and clinical data have suggested that angiotension converting enzyme (ACE) inhibitors may decrease glomerular proteinuria by specific effects on the glomerulus. We studied a group of 15 adult patients with chronic renal failure and proteinuria due to various glomerulopathies. These patients had mild to moderate hypertension which was effectively controlled with conventional antihypertensive therapy. We then treated the patients with captopril, maintaining a similar dietary protein and salt intake. After 6 months of study, proteinuria was reduced significantly without reduction in inulin or para-aminohipurrate clearance. This supports the concept that captopril may have salutary effects on the glomerulus, independently of its effect on systemic blood pressure.

Original languageEnglish (US)
Pages (from-to)S467-S469
JournalJournal of Hypertension, Supplement
Volume6
Issue number4
StatePublished - Dec 1988

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Keywords

  • Angiotensin converting enzyme inhibitor
  • Arterial hypertension
  • Captopril
  • Glomerulonephritis
  • Proteinuria

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Ruilope, L. M., Miranda, B., Oliet, A., Millet, V. G., Rodicio, J. L., Carlos Romero, J., & Raij, L. (1988). Control of hypertension with the angiotensin converting enzyme inhibitor captopril reduces glomerular proteinuria. Journal of Hypertension, Supplement, 6(4), S467-S469.