Control of hair growth with parathyroid hormone (7-34)

Marcus B. Schilli, Swapna Ray, Ralf Paus, Eliot Obi-Tabot, Michael F. Holick

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Parathyroid hormone (PTH) related peptide (PTHrP) is thought to influence the proliferation and differentiation of the epidermis and hair follicle. As a means of elucidating the biologic function of PTHrP on the hair follicle, a PTHrP analog PTH (7-34), which is a PTH/PTHrP receptor antagonist, was given intraperitoneally twice daily to C57 BL/6 mice at different stages of the hair cycle. PTH (7-34) induced 99 ± 4.5% (mean ± SEM)of resting telogen hair follicles into a proliferative (anagen) state, whereas 100% of the hair follicles in the control group remained in telogen. To determine whether this pep-tide influenced the progression of the hair follicles from anagen to catagen (hair follicle maturation and regression), groups of mice that were either spontaneously in or induced to anagen received either PTH (7-34) or placebo. Morphometric analysis of the hair follicles from the middle back region of the spontaneous anagen mice that received PTH (7-34) revealed that 19 ± 4% (mean ± SEM) of the follicles were in anagen VI, whereas none (0%) were in anagen in the control group. Similarly, in induced anagen mice treated with PTH (7-34), 22.3 ± 1.4 (mean ± SEM) of the follicles were in anagen VI compared to only 1.3 ± 0.7% in the control mice. Together these observations suggest that PTHrP is a hair follicle morphogen that may be a major factor responsible for controlling the hair cycle. These studies provide a new insight for development of PTHrP analogs for a wide variety of disorders related to disturbances of hair cycling.

Original languageEnglish (US)
Pages (from-to)928-932
Number of pages5
JournalJournal of Investigative Dermatology
Volume108
Issue number6
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Fingerprint

Parathyroid Hormone-Related Protein
Hair Follicle
Hair
Growth
Scanning electron microscopy
Parathyroid Hormone Receptor Type 1
Tides
Parathyroid Hormone
Control Groups
parathyroid hormone (7-34)
Epidermis
Placebos

Keywords

  • Anagen
  • Hair cycle
  • Mice
  • Parathyroid hormone related peptide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Control of hair growth with parathyroid hormone (7-34). / Schilli, Marcus B.; Ray, Swapna; Paus, Ralf; Obi-Tabot, Eliot; Holick, Michael F.

In: Journal of Investigative Dermatology, Vol. 108, No. 6, 01.01.1997, p. 928-932.

Research output: Contribution to journalArticle

Schilli, Marcus B. ; Ray, Swapna ; Paus, Ralf ; Obi-Tabot, Eliot ; Holick, Michael F. / Control of hair growth with parathyroid hormone (7-34). In: Journal of Investigative Dermatology. 1997 ; Vol. 108, No. 6. pp. 928-932.
@article{e7c11540fac64b39aff8341ed9ff0c59,
title = "Control of hair growth with parathyroid hormone (7-34)",
abstract = "Parathyroid hormone (PTH) related peptide (PTHrP) is thought to influence the proliferation and differentiation of the epidermis and hair follicle. As a means of elucidating the biologic function of PTHrP on the hair follicle, a PTHrP analog PTH (7-34), which is a PTH/PTHrP receptor antagonist, was given intraperitoneally twice daily to C57 BL/6 mice at different stages of the hair cycle. PTH (7-34) induced 99 ± 4.5{\%} (mean ± SEM)of resting telogen hair follicles into a proliferative (anagen) state, whereas 100{\%} of the hair follicles in the control group remained in telogen. To determine whether this pep-tide influenced the progression of the hair follicles from anagen to catagen (hair follicle maturation and regression), groups of mice that were either spontaneously in or induced to anagen received either PTH (7-34) or placebo. Morphometric analysis of the hair follicles from the middle back region of the spontaneous anagen mice that received PTH (7-34) revealed that 19 ± 4{\%} (mean ± SEM) of the follicles were in anagen VI, whereas none (0{\%}) were in anagen in the control group. Similarly, in induced anagen mice treated with PTH (7-34), 22.3 ± 1.4 (mean ± SEM) of the follicles were in anagen VI compared to only 1.3 ± 0.7{\%} in the control mice. Together these observations suggest that PTHrP is a hair follicle morphogen that may be a major factor responsible for controlling the hair cycle. These studies provide a new insight for development of PTHrP analogs for a wide variety of disorders related to disturbances of hair cycling.",
keywords = "Anagen, Hair cycle, Mice, Parathyroid hormone related peptide",
author = "Schilli, {Marcus B.} and Swapna Ray and Ralf Paus and Eliot Obi-Tabot and Holick, {Michael F.}",
year = "1997",
month = "1",
day = "1",
doi = "10.1111/1523-1747.ep12294690",
language = "English (US)",
volume = "108",
pages = "928--932",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Control of hair growth with parathyroid hormone (7-34)

AU - Schilli, Marcus B.

AU - Ray, Swapna

AU - Paus, Ralf

AU - Obi-Tabot, Eliot

AU - Holick, Michael F.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Parathyroid hormone (PTH) related peptide (PTHrP) is thought to influence the proliferation and differentiation of the epidermis and hair follicle. As a means of elucidating the biologic function of PTHrP on the hair follicle, a PTHrP analog PTH (7-34), which is a PTH/PTHrP receptor antagonist, was given intraperitoneally twice daily to C57 BL/6 mice at different stages of the hair cycle. PTH (7-34) induced 99 ± 4.5% (mean ± SEM)of resting telogen hair follicles into a proliferative (anagen) state, whereas 100% of the hair follicles in the control group remained in telogen. To determine whether this pep-tide influenced the progression of the hair follicles from anagen to catagen (hair follicle maturation and regression), groups of mice that were either spontaneously in or induced to anagen received either PTH (7-34) or placebo. Morphometric analysis of the hair follicles from the middle back region of the spontaneous anagen mice that received PTH (7-34) revealed that 19 ± 4% (mean ± SEM) of the follicles were in anagen VI, whereas none (0%) were in anagen in the control group. Similarly, in induced anagen mice treated with PTH (7-34), 22.3 ± 1.4 (mean ± SEM) of the follicles were in anagen VI compared to only 1.3 ± 0.7% in the control mice. Together these observations suggest that PTHrP is a hair follicle morphogen that may be a major factor responsible for controlling the hair cycle. These studies provide a new insight for development of PTHrP analogs for a wide variety of disorders related to disturbances of hair cycling.

AB - Parathyroid hormone (PTH) related peptide (PTHrP) is thought to influence the proliferation and differentiation of the epidermis and hair follicle. As a means of elucidating the biologic function of PTHrP on the hair follicle, a PTHrP analog PTH (7-34), which is a PTH/PTHrP receptor antagonist, was given intraperitoneally twice daily to C57 BL/6 mice at different stages of the hair cycle. PTH (7-34) induced 99 ± 4.5% (mean ± SEM)of resting telogen hair follicles into a proliferative (anagen) state, whereas 100% of the hair follicles in the control group remained in telogen. To determine whether this pep-tide influenced the progression of the hair follicles from anagen to catagen (hair follicle maturation and regression), groups of mice that were either spontaneously in or induced to anagen received either PTH (7-34) or placebo. Morphometric analysis of the hair follicles from the middle back region of the spontaneous anagen mice that received PTH (7-34) revealed that 19 ± 4% (mean ± SEM) of the follicles were in anagen VI, whereas none (0%) were in anagen in the control group. Similarly, in induced anagen mice treated with PTH (7-34), 22.3 ± 1.4 (mean ± SEM) of the follicles were in anagen VI compared to only 1.3 ± 0.7% in the control mice. Together these observations suggest that PTHrP is a hair follicle morphogen that may be a major factor responsible for controlling the hair cycle. These studies provide a new insight for development of PTHrP analogs for a wide variety of disorders related to disturbances of hair cycling.

KW - Anagen

KW - Hair cycle

KW - Mice

KW - Parathyroid hormone related peptide

UR - http://www.scopus.com/inward/record.url?scp=0030987906&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030987906&partnerID=8YFLogxK

U2 - 10.1111/1523-1747.ep12294690

DO - 10.1111/1523-1747.ep12294690

M3 - Article

C2 - 9182824

AN - SCOPUS:0030987906

VL - 108

SP - 928

EP - 932

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 6

ER -