Control of gonadotropic hormone release in trout: Influence of synthetic LHRH and LHRH analogues in vivo and in vitro

L. W. Crim; D. M. Evans; D. H. Coy; A. V. Schally

doi:10.1016/0024-3205(81)90544-0

Control of gonadotropic hormone release in trout: Influence of synthetic LHRH and LHRH analogues in vivo and in vitro

L. W. Crim, D. M. Evans, D. H. Coy, A. V. Schally

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Studies were conducted to determine the influence of some LHRH analogues on gonadotropic hormone (GtH) secretion in two species of trout. The observations indicated that synthetic LHRH and various stimulatory LHRH analogues are approximately equipotent in these fish. This is an unexpected result considering the superactive properties of these analogues demonstrated in mammals. An inhibitory LHRH analogue was also tested in the trout with the result that powerful inhibition of LHRH induced GtH release was obtained.

Original language	English (US)
Pages (from-to)	129-135
Number of pages	7
Journal	Life Sciences
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/0024-3205(81)90544-0
State	Published - Jan 12 1981
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Control of gonadotropic hormone release in trout: Influence of synthetic LHRH and LHRH analogues in vivo and in vitro",

abstract = "Studies were conducted to determine the influence of some LHRH analogues on gonadotropic hormone (GtH) secretion in two species of trout. The observations indicated that synthetic LHRH and various stimulatory LHRH analogues are approximately equipotent in these fish. This is an unexpected result considering the superactive properties of these analogues demonstrated in mammals. An inhibitory LHRH analogue was also tested in the trout with the result that powerful inhibition of LHRH induced GtH release was obtained.",

author = "Crim, {L. W.} and Evans, {D. M.} and Coy, {D. H.} and Schally, {A. V.}",

note = "Funding Information: The authors wish to express their appreciation for the generous donatxon of LH-RH (lot 21-103-DH) from The National Institutes of Health (NIAMDD). This work was supported by the Natural Sciences and Engineering Research Councxl of Canada with Grant A9729 to L. Crim, Marine Sciences Research Laboratory, Contrxbution Number 389.",

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AU - Evans, D. M.

AU - Coy, D. H.

AU - Schally, A. V.

N1 - Funding Information: The authors wish to express their appreciation for the generous donatxon of LH-RH (lot 21-103-DH) from The National Institutes of Health (NIAMDD). This work was supported by the Natural Sciences and Engineering Research Councxl of Canada with Grant A9729 to L. Crim, Marine Sciences Research Laboratory, Contrxbution Number 389.

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AB - Studies were conducted to determine the influence of some LHRH analogues on gonadotropic hormone (GtH) secretion in two species of trout. The observations indicated that synthetic LHRH and various stimulatory LHRH analogues are approximately equipotent in these fish. This is an unexpected result considering the superactive properties of these analogues demonstrated in mammals. An inhibitory LHRH analogue was also tested in the trout with the result that powerful inhibition of LHRH induced GtH release was obtained.

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Control of gonadotropic hormone release in trout: Influence of synthetic LHRH and LHRH analogues in vivo and in vitro

Abstract

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