Contributors to neuropsychological impairment in HIV-infected and HIV-uninfected opiate-dependent patients

Allison J. Applebaum, Michael W. Otto, Mark A. Richardson, Steven A. Safren

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Neuropsychological (NP) impairment is multiply determined among HIV-infected and HIV-uninfected individuals who are also dually diagnosed with depression and who use illicit substances. The purpose of the present study was to assess the impact of HIV status, depression, and problematic substance use on NP performance. A total of 160 opiate-dependent outpatients undergoing methadone maintenance (80 HIV-infected, 80 HIV-uninfected) completed diagnostic and NP evaluations. Raw scores from individual NP tests were converted to Z scores relative to standard norms and were averaged to form a composite score. HIV-infected participants had significantly lower overall NP performanceas well as lower performance on tests of attention, motor speed, and verbal memorythan HIV-uninfected participants. In multiple regression analyses considering the role of depression and substance use, only HIV status emerged as a significant predictor of NP impairment. These findings confirm NP impairment in HIV-infected substance abusing patients independent of comorbid depression and severity of substance use.

Original languageEnglish (US)
Pages (from-to)579-589
Number of pages11
JournalJournal of Clinical and Experimental Neuropsychology
Issue number6
StatePublished - Jul 2010
Externally publishedYes


  • Depression
  • HIV
  • Methadone maintenance therapy
  • Neuropsychological impairment
  • Opiate dependence

ASJC Scopus subject areas

  • Clinical Psychology
  • Neurology
  • Clinical Neurology


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