Contributions of protein kinase A anchoring proteins to compartmentation of cAMP signaling in the heart

Michael S Kapiloff

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The cAMP-dependent protein kinase (PKA) transduces signals in the heart initiated by β1-adrenergic, G-protein-coupled receptors after norepinephrine, sympathetic stimulation. Signaling through this pathway results in a characteristic set of cellular responses, including increases in ion fluxes and contractile strength, mobilization of energy stores, and changes in gene expression. Not all receptors that activate adenylate cyclase and increase cAMP levels, however, cause the cardiac myocyte to react in this manner. Research in the field of signal transduction over the last 25 years has addressed this issue of specificity in signaling by diffusable second messengers. PKA is in part targeted to discrete cellular locations by A-kinase anchoring proteins. Through anchoring and formation of multienzyme complexes, specific, localized signal transduction is possible. I discuss in this review recent advances in the understanding of PKA signaling complexes in the cardiac myocyte.

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalMolecular Pharmacology
Volume62
Issue number2
DOIs
StatePublished - Aug 3 2002
Externally publishedYes

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Cyclic AMP-Dependent Protein Kinases
Protein Kinases
Cardiac Myocytes
Signal Transduction
Multienzyme Complexes
Proteins
Second Messenger Systems
G-Protein-Coupled Receptors
Adenylyl Cyclases
Adrenergic Agents
Norepinephrine
Ions
Gene Expression
Research

ASJC Scopus subject areas

  • Pharmacology

Cite this

Contributions of protein kinase A anchoring proteins to compartmentation of cAMP signaling in the heart. / Kapiloff, Michael S.

In: Molecular Pharmacology, Vol. 62, No. 2, 03.08.2002, p. 193-199.

Research output: Contribution to journalArticle

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