Contributions of protein kinase A anchoring proteins to compartmentation of cAMP signaling in the heart

Michael S. Kapiloff

Research output: Contribution to journalShort survey

36 Scopus citations

Abstract

The cAMP-dependent protein kinase (PKA) transduces signals in the heart initiated by β1-adrenergic, G-protein-coupled receptors after norepinephrine, sympathetic stimulation. Signaling through this pathway results in a characteristic set of cellular responses, including increases in ion fluxes and contractile strength, mobilization of energy stores, and changes in gene expression. Not all receptors that activate adenylate cyclase and increase cAMP levels, however, cause the cardiac myocyte to react in this manner. Research in the field of signal transduction over the last 25 years has addressed this issue of specificity in signaling by diffusable second messengers. PKA is in part targeted to discrete cellular locations by A-kinase anchoring proteins. Through anchoring and formation of multienzyme complexes, specific, localized signal transduction is possible. I discuss in this review recent advances in the understanding of PKA signaling complexes in the cardiac myocyte.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalMolecular Pharmacology
Volume62
Issue number2
DOIs
StatePublished - Aug 3 2002

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Fingerprint Dive into the research topics of 'Contributions of protein kinase A anchoring proteins to compartmentation of cAMP signaling in the heart'. Together they form a unique fingerprint.

  • Cite this