Contributions of HIV, hepatitis C virus, and traditional vascular risk factors to peripheral artery disease in women

Emily Cedarbaum, Yifei Ma, Rebecca Scherzer, Jennifer C. Price, Adaora A. Adimora, Marcas Bamman, Mardge Cohen, Margaret A. Fischl, Kunihiro Matsushita, Igho Ofotokun, Michael Plankey, Eric C. Seaberg, Michael T. Yin, Carl Grunfeld, Shant Vartanian, Anjali Sharma, Phyllis C. Tien

Research output: Contribution to journalArticle

Abstract

Objectives:HIV and hepatitis C virus (HCV) have been associated with cardiovascular disease (CVD), but it is unclear whether HIV and HCV are also associated with peripheral artery disease (PAD). We examined the association of HIV, HCV, and traditional CVD risk factors with PAD in the Women's Interagency HIV Study, a multicenter US cohort.Methods:In this cross-sectional study, ankle-brachial index was estimated using Doppler ultrasound and manual sphygmomanometer in 1899 participants aged more than 40 years with HIV/HCV coinfection, HCV or HIV monoinfection, or neither infection. Multivariable logistic regression was used to estimate the odds of PAD (ankle-brachial index ≤0.9) after controlling for demographic, behavioral, and CVD risk factors.Results:Over two-thirds were African-American, median age was 50 years, and PAD prevalence was 7.7% with little difference by infection status. After multivariable adjustment, neither HIV nor HCV infection was associated with greater odds of PAD. Factors associated with PAD included older age [adjusted odds ratio (aOR): 2.01 for age 61-70 vs. 40-50 years; 95% confidence interval (CI): 1.04, 3.87], Black race (aOR: 2.30; 95% CI: 1.15, 4.63), smoking (aOR: 1.27 per 10-pack-year increment; 95% CI: 1.09, 1.48), and higher SBP (aOR: 1.14 per 10 mmHg; 95% CI: 1.01, 1.28).Conclusion:The high PAD prevalence in this nationally representative cohort of women with or at risk for HIV is on par with general population studies in individuals a decade older than our study's median age. HIV and HCV infection are not associated with greater PAD risk relative to uninfected women with similar risk factors. Modifiable traditional CVD risk factors may be important early intervention targets in women with and at risk for HIV.

Original languageEnglish (US)
Pages (from-to)2025-2033
Number of pages9
JournalAIDS
Volume33
Issue number13
DOIs
StatePublished - Nov 1 2019

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Peripheral Arterial Disease
Hepacivirus
HIV
Cardiovascular Diseases
Odds Ratio
Confidence Intervals
Ankle Brachial Index
Virus Diseases
vascular factor
Sphygmomanometers
Social Adjustment
Doppler Ultrasonography
Infection
Coinfection
African Americans
Multicenter Studies
Cross-Sectional Studies
Logistic Models
Smoking
Demography

Keywords

  • ankle-brachial index
  • hepatitis C
  • HIV
  • peripheral arterial disease
  • women

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Cedarbaum, E., Ma, Y., Scherzer, R., Price, J. C., Adimora, A. A., Bamman, M., ... Tien, P. C. (2019). Contributions of HIV, hepatitis C virus, and traditional vascular risk factors to peripheral artery disease in women. AIDS, 33(13), 2025-2033. https://doi.org/10.1097/QAD.0000000000002319

Contributions of HIV, hepatitis C virus, and traditional vascular risk factors to peripheral artery disease in women. / Cedarbaum, Emily; Ma, Yifei; Scherzer, Rebecca; Price, Jennifer C.; Adimora, Adaora A.; Bamman, Marcas; Cohen, Mardge; Fischl, Margaret A.; Matsushita, Kunihiro; Ofotokun, Igho; Plankey, Michael; Seaberg, Eric C.; Yin, Michael T.; Grunfeld, Carl; Vartanian, Shant; Sharma, Anjali; Tien, Phyllis C.

In: AIDS, Vol. 33, No. 13, 01.11.2019, p. 2025-2033.

Research output: Contribution to journalArticle

Cedarbaum, E, Ma, Y, Scherzer, R, Price, JC, Adimora, AA, Bamman, M, Cohen, M, Fischl, MA, Matsushita, K, Ofotokun, I, Plankey, M, Seaberg, EC, Yin, MT, Grunfeld, C, Vartanian, S, Sharma, A & Tien, PC 2019, 'Contributions of HIV, hepatitis C virus, and traditional vascular risk factors to peripheral artery disease in women', AIDS, vol. 33, no. 13, pp. 2025-2033. https://doi.org/10.1097/QAD.0000000000002319
Cedarbaum, Emily ; Ma, Yifei ; Scherzer, Rebecca ; Price, Jennifer C. ; Adimora, Adaora A. ; Bamman, Marcas ; Cohen, Mardge ; Fischl, Margaret A. ; Matsushita, Kunihiro ; Ofotokun, Igho ; Plankey, Michael ; Seaberg, Eric C. ; Yin, Michael T. ; Grunfeld, Carl ; Vartanian, Shant ; Sharma, Anjali ; Tien, Phyllis C. / Contributions of HIV, hepatitis C virus, and traditional vascular risk factors to peripheral artery disease in women. In: AIDS. 2019 ; Vol. 33, No. 13. pp. 2025-2033.
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abstract = "Objectives:HIV and hepatitis C virus (HCV) have been associated with cardiovascular disease (CVD), but it is unclear whether HIV and HCV are also associated with peripheral artery disease (PAD). We examined the association of HIV, HCV, and traditional CVD risk factors with PAD in the Women's Interagency HIV Study, a multicenter US cohort.Methods:In this cross-sectional study, ankle-brachial index was estimated using Doppler ultrasound and manual sphygmomanometer in 1899 participants aged more than 40 years with HIV/HCV coinfection, HCV or HIV monoinfection, or neither infection. Multivariable logistic regression was used to estimate the odds of PAD (ankle-brachial index ≤0.9) after controlling for demographic, behavioral, and CVD risk factors.Results:Over two-thirds were African-American, median age was 50 years, and PAD prevalence was 7.7{\%} with little difference by infection status. After multivariable adjustment, neither HIV nor HCV infection was associated with greater odds of PAD. Factors associated with PAD included older age [adjusted odds ratio (aOR): 2.01 for age 61-70 vs. 40-50 years; 95{\%} confidence interval (CI): 1.04, 3.87], Black race (aOR: 2.30; 95{\%} CI: 1.15, 4.63), smoking (aOR: 1.27 per 10-pack-year increment; 95{\%} CI: 1.09, 1.48), and higher SBP (aOR: 1.14 per 10 mmHg; 95{\%} CI: 1.01, 1.28).Conclusion:The high PAD prevalence in this nationally representative cohort of women with or at risk for HIV is on par with general population studies in individuals a decade older than our study's median age. HIV and HCV infection are not associated with greater PAD risk relative to uninfected women with similar risk factors. Modifiable traditional CVD risk factors may be important early intervention targets in women with and at risk for HIV.",
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AU - Cedarbaum, Emily

AU - Ma, Yifei

AU - Scherzer, Rebecca

AU - Price, Jennifer C.

AU - Adimora, Adaora A.

AU - Bamman, Marcas

AU - Cohen, Mardge

AU - Fischl, Margaret A.

AU - Matsushita, Kunihiro

AU - Ofotokun, Igho

AU - Plankey, Michael

AU - Seaberg, Eric C.

AU - Yin, Michael T.

AU - Grunfeld, Carl

AU - Vartanian, Shant

AU - Sharma, Anjali

AU - Tien, Phyllis C.

PY - 2019/11/1

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N2 - Objectives:HIV and hepatitis C virus (HCV) have been associated with cardiovascular disease (CVD), but it is unclear whether HIV and HCV are also associated with peripheral artery disease (PAD). We examined the association of HIV, HCV, and traditional CVD risk factors with PAD in the Women's Interagency HIV Study, a multicenter US cohort.Methods:In this cross-sectional study, ankle-brachial index was estimated using Doppler ultrasound and manual sphygmomanometer in 1899 participants aged more than 40 years with HIV/HCV coinfection, HCV or HIV monoinfection, or neither infection. Multivariable logistic regression was used to estimate the odds of PAD (ankle-brachial index ≤0.9) after controlling for demographic, behavioral, and CVD risk factors.Results:Over two-thirds were African-American, median age was 50 years, and PAD prevalence was 7.7% with little difference by infection status. After multivariable adjustment, neither HIV nor HCV infection was associated with greater odds of PAD. Factors associated with PAD included older age [adjusted odds ratio (aOR): 2.01 for age 61-70 vs. 40-50 years; 95% confidence interval (CI): 1.04, 3.87], Black race (aOR: 2.30; 95% CI: 1.15, 4.63), smoking (aOR: 1.27 per 10-pack-year increment; 95% CI: 1.09, 1.48), and higher SBP (aOR: 1.14 per 10 mmHg; 95% CI: 1.01, 1.28).Conclusion:The high PAD prevalence in this nationally representative cohort of women with or at risk for HIV is on par with general population studies in individuals a decade older than our study's median age. HIV and HCV infection are not associated with greater PAD risk relative to uninfected women with similar risk factors. Modifiable traditional CVD risk factors may be important early intervention targets in women with and at risk for HIV.

AB - Objectives:HIV and hepatitis C virus (HCV) have been associated with cardiovascular disease (CVD), but it is unclear whether HIV and HCV are also associated with peripheral artery disease (PAD). We examined the association of HIV, HCV, and traditional CVD risk factors with PAD in the Women's Interagency HIV Study, a multicenter US cohort.Methods:In this cross-sectional study, ankle-brachial index was estimated using Doppler ultrasound and manual sphygmomanometer in 1899 participants aged more than 40 years with HIV/HCV coinfection, HCV or HIV monoinfection, or neither infection. Multivariable logistic regression was used to estimate the odds of PAD (ankle-brachial index ≤0.9) after controlling for demographic, behavioral, and CVD risk factors.Results:Over two-thirds were African-American, median age was 50 years, and PAD prevalence was 7.7% with little difference by infection status. After multivariable adjustment, neither HIV nor HCV infection was associated with greater odds of PAD. Factors associated with PAD included older age [adjusted odds ratio (aOR): 2.01 for age 61-70 vs. 40-50 years; 95% confidence interval (CI): 1.04, 3.87], Black race (aOR: 2.30; 95% CI: 1.15, 4.63), smoking (aOR: 1.27 per 10-pack-year increment; 95% CI: 1.09, 1.48), and higher SBP (aOR: 1.14 per 10 mmHg; 95% CI: 1.01, 1.28).Conclusion:The high PAD prevalence in this nationally representative cohort of women with or at risk for HIV is on par with general population studies in individuals a decade older than our study's median age. HIV and HCV infection are not associated with greater PAD risk relative to uninfected women with similar risk factors. Modifiable traditional CVD risk factors may be important early intervention targets in women with and at risk for HIV.

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