Contrast-induced nephropathy in patients undergoing computed tomography (CONNECT) - A clinical problem in daily practice? A multicenter observational study

Riccardo Lencioni, Rossella Fattori, Giovanni Morana, Fulvio Stacul

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Although several studies have examined contrast-induced nephropathy (CIN) following computed tomography (CT) procedures under closely controlled clinical trial conditions, less is known about the incidence of CIN (or its key predictive factors) in a "real world" clinical setting. Purpose: A multicenter, observational registry study was undertaken in Italian hospital radiology departments to retrospectively assess the incidence of CIN in at-risk patients undergoing iodixanol-enhanced CT procedures. Material and Methods: Each department used center-specific (nonstandardized) CT protocols. Data were available from 493 at-risk patients; most (76.4%) had 1 risk factor for CIN, 19.8% had 2, and 3.4% had 3. In all, 169 patients (34.3%) had reduced renal function (estimated glomerular filtration rate [eGFR] 2). Prophylactic volume expansion was not used in 70.6% of the study population. Results: The overall incidence of CIN (defined as a ≥44.2 μmol/l [0.5 mg/dl] increase in serum creatinine from baseline 72 h postprocedure) was 2.6%; in the subpopulation of patients with renal impairment (with or without other risk factors), CIN incidence was 4.7%. Multivariate analysis identified renal insufficiency as the only risk factor predictive of CIN (relative risk, 3.850; 95% confidence interval, 1.20012.348; P0.023). Conclusion: In the clinical setting of hospital CT radiology practice, where guideline-recommended strategies for CIN prevention may not be consistently followed, use of the iso-osmolar agent iodixanol appears to be associated with a low incidence of CIN in at-risk patients.

Original languageEnglish (US)
Pages (from-to)741-750
Number of pages10
JournalActa Radiologica
Volume51
Issue number7
DOIs
StatePublished - Sep 2010
Externally publishedYes

Fingerprint

Multicenter Studies
Observational Studies
Tomography
Incidence
Hospital Radiology Department
Kidney
Controlled Clinical Trials
Glomerular Filtration Rate
Practice Guidelines
Radiology
Renal Insufficiency
Registries
Creatinine
Multivariate Analysis
Confidence Intervals
Serum
Population
iodixanol

Keywords

  • CT
  • Intravenous contrast agents
  • Kidney
  • Vascular

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

Cite this

Contrast-induced nephropathy in patients undergoing computed tomography (CONNECT) - A clinical problem in daily practice? A multicenter observational study. / Lencioni, Riccardo; Fattori, Rossella; Morana, Giovanni; Stacul, Fulvio.

In: Acta Radiologica, Vol. 51, No. 7, 09.2010, p. 741-750.

Research output: Contribution to journalArticle

Lencioni, Riccardo ; Fattori, Rossella ; Morana, Giovanni ; Stacul, Fulvio. / Contrast-induced nephropathy in patients undergoing computed tomography (CONNECT) - A clinical problem in daily practice? A multicenter observational study. In: Acta Radiologica. 2010 ; Vol. 51, No. 7. pp. 741-750.
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