Contrast enhanced multi-detector computed tomography coronary angiography versus conventional invasive quantitative coronary angiography in acute coronary syndrome patients-correlation and bias

Robert Dragu, Shmuel Rispler, Eduard Ghersin, Luis Gruberg, Jonathan Lessick, Diana Litmanovich, Doron Aronson, Haim Hammerman, Amos Ofer, Ahuva Engel, Rafael Beyar

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background: Previous studies that compared multi-detector computed tomography (MDCT) non-invasive coronary angiography with conventional coronary angiography, did not assessed the ability of MDCT to detect stenotic lesions correctly in acute coronary syndromes (ACS) patients. The aim of the present study was to assess prospectively the correlation and bias between 16-slice MDCT coronary angiography and quantitative coronary angiography analysis (QCA) in these patients. Methods: Patients underwent electrocardiogram-gated, 16-slice MDCT coronary angiography and routine invasive percutaneous coronary angiography with quantitative coronary angiography (QCA) analysis blinded to MDCT results. The correlation and the bias between the results of MDCT and QCA were assessed in segments observed by both modalities in vessels≥2 mm in diameter. Results: 59 patients (81% male, age 56±11 years), admitted due to ACS, underwent MDCT and invasive coronary angiography. 544 segments were analyzed. The correlations between MDCT and QCA observed for the left anterior descending coronary artery (LAD), the left circumflex coronary artery (Cx), the right coronary artery (RCA) and for all analyzed segments were 0.74 ( P<0.0001), 0.54 (P<0.009), 0.72 (P<0.0001) and 0.70 (P<0.0001), respectively. By Bland-Altman analysis, a small overestimation of the lesion severity with MDCT of 4.8% for the LAD, 5.9% for the Cx, and 3.3% for the RCA was observed. Conclusions: In ACS patients, MDCT contrast-enhanced coronary angiography provides good quantification of the luminal diameter as compared to coronary angiography, and it is characterized by a small overestimation bias.

Original languageEnglish (US)
Pages (from-to)99-104
Number of pages6
JournalAcute Cardiac Care
Volume8
Issue number2
DOIs
StatePublished - Jul 1 2006
Externally publishedYes

Keywords

  • Acute coronary syndrome
  • Multi-detector computed tomography
  • Quantitative coronary angiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Emergency Medicine

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