Continuous dermoepidermal junction IgM detected by direct immunofluorescence: a report of nine cases.

T. N. Helm, R. Valenzuela

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Although a linear IgM dermatosis of pregnancy has been reported, other authors have not found evidence for a distinct linear IgM dermatosis. OBJECTIVE: We set out to determine whether or not continuous dermoepidermal junction IgM deposition detected by direct immunofluorescence was indicative of a specific disease. METHODS: We collected nine cases during a 9-year period in which biopsy specimens for direct immunofluorescence revealed continuous linear IgM at the dermoepidermal junction in the absence of other immunoglobulins. In all of these cases the medical record was available for review. RESULTS: Clinical correlation revealed that these patients had a heterogeneous group of diseases with urticaria and leukocytoclastic vasculitis being most common. No diagnostic specificity could be ascribed to the linear IgM pattern, although six of our nine cases could be considered manifestations of a hypersensitivity response (e.g., urticaria, leukocytoclastic vasculitis, pigmented purpuric dermatosis, or hypersensitivity dermatitis). CONCLUSION: Pathologists and dermatologists should be aware that linear IgM can be seen in a variety of clinical settings. The etiopathogenic significance of this finding, if any, remains to be determined. At present, the finding must be viewed as nonspecific.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume26
Issue number2 Pt 1
StatePublished - Feb 1 1992
Externally publishedYes

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Direct Fluorescent Antibody Technique
Immunoglobulin M
Skin Diseases
Urticaria
Hypersensitivity
Dermatitis
Medical Records
Immunoglobulins
Biopsy
Pregnancy

ASJC Scopus subject areas

  • Dermatology

Cite this

Continuous dermoepidermal junction IgM detected by direct immunofluorescence : a report of nine cases. / Helm, T. N.; Valenzuela, R.

In: Journal of the American Academy of Dermatology, Vol. 26, No. 2 Pt 1, 01.02.1992, p. 203-206.

Research output: Contribution to journalArticle

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