Continuous cocaine administration enhances μ- But not ο-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens

Sari Izenwasser, Brett Heller, Brian M. Cox

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Cocaine alters opioid receptor densities in rat brain. To investigate the functional consequences of such opioid receptor changes, adenylyl cyclase activity was measured in rat nucleus accumbens and caudate putamen following continuous cocaine administration (50 mg/kg/day, 7 days). In the nucleus accumbens chronic cocaine led to an increase in both the number of μ-opioid receptors and the maximal inhibition of adenylyl cyclase activity by DAMGO ([D-Ala2,N-methyl-Phe4,Glyol]enkephalin). There was no effect on inhibition of adenylyl cyclase activity by DPDPE ([D-Pen2,D-Pen5]enkephalin). There were no changes in the caudate putamen. Thus, continuous cocaine administration for 7 days results in a selective increase in μ-opioid receptor-mediated effector function in the nucleus accumbens.

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalEuropean Journal of Pharmacology
Volume297
Issue number1-2
DOIs
StatePublished - Feb 15 1996
Externally publishedYes

Keywords

  • Caudate
  • Cocaine
  • Nucleus accumbens
  • Opioid

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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