Contemporary trends of hospitalization for atrial fibrillation in the united states, 2000 through 2010 implications for healthcare planning

Nileshkumar J. Patel, Abhishek Deshmukh, Sadip Pant, Vikas Singh, Nilay Patel, Shilpkumar Arora, Neeraj Shah, Ankit Chothani, Ghanshyambhai T. Savani, Kathan Mehta, Valay Parikh, Ankit Rathod, Apurva O. Badheka, James Lafferty, Marcin Kowalski, Jawahar L. Mehta, Raul D. Mitrani, Juan F. Viles-Gonzalez, Hakan Paydak

Research output: Contribution to journalReview articlepeer-review

241 Scopus citations


Background-Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The associated morbidity and mortality make AF a major public health burden. Hospitalizations account for the majority of the economic cost burden associated with AF. The main objective of this study is to examine the trends of AF-related hospitalizations in the United States and to compare patient characteristics, outcomes, and comorbid diagnoses. Methods and Results-With the use of the Nationwide Inpatient Sample from 2000 through 2010, we identified AF-related hospitalizations using International Classification of Diseases, 9th Revision, Clinical Modification code 427.31 as the principal discharge diagnosis. Overall AF hospitalizations increased by 23% from 2000 to 2010, particularly in patients =65 years of age. The most frequent coexisting conditions were hypertension (60.0%), diabetes mellitus (21.5%), and chronic pulmonary disease (20.0%). Overall in-hospital mortality was 1%. The mortality rate was highest in the group of patients =80 years of age (1.9%) and in the group of patients with concomitant heart failure (8.2%). In-hospital mortality rate decreased significantly from 1.2% in 2000 to 0.9% in 2010 (29.2% decrease; P<0.001). Although there was no significant change in mean length of stay, mean cost of AF hospitalization increased significantly from $6410 in 2001 to $8439 in 2010 (24.0% increase; P<0.001). Conclusions- Hospitalization rates for AF have increased exponentially among US adults from 2000 to 2010. The proportion of comorbid chronic diseases has also increased significantly. The last decade has witnessed an overall decline in hospital mortality; however, the hospitalization cost has significantly increased.

Original languageEnglish (US)
Pages (from-to)2371-2379
Number of pages9
Issue number23
StatePublished - Jun 10 2014


  • Atrial fibrillation
  • Cost
  • Hospitalization

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine


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