Abstract
The frequency of positive reactions to 5‐chloro‐2‐methyl‐4‐isothiazolin‐3‐one (MCI/MI) were studied at 22 European cntact dermatitis clinics over a period of 1 year. A total of 4713 patients participated. All the patients were patch tested with nickel sulphate, formaldehyde, paraben‐mix, and MCI/MI 19.4% of the patients had positive patch tests to nickel, making this the most common allergen, 3% of the patients reacted to 100 ppm MCI/MI, while 2.6% reacted to formaldchyde and 1.1% to parabens. There was great variation in the frequency of MCI/MI sensitivity among the 22 centres. MCI/MI contact allergy was most common among women and in patients with facial dermatitis, while it was rarely seen in patients with dermatitis on the lower legs. There were no fluctuations in the number of positive patch tests to MCI/MI on a monthly basis when the results from all centres were combined. 117 of the 141 MCI/MI sensitized patients included in the study were retested 88% had positive patch tests when retested. 101 of the MCI/MI‐sensitive patients participated in a double ‐blind, placebo‐controlled product use test. This test showed that 31% of the MCI/MI‐sensitive patients had a positive reaction to a MCI/MI‐preserved product. Only a few patients reacted to a control product. It is concluded that the preservative MCI/MI is an important new contact allergen.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 334-341 |
| Number of pages | 8 |
| Journal | Contact Dermatitis |
| Volume | 24 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1991 |
| Externally published | Yes |
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Keywords
- 2‐methyl‐4‐isothiazolin‐3‐one
- 5‐chloro‐2‐methyl‐4‐isothiazolin‐3‐one
- contact allergy
- cosmetics
- formaldehyde
- multicentre study
- nickel
- parabens
- patch testing technique
- preservatives
ASJC Scopus subject areas
- Immunology and Allergy
- Dermatology
Cite this
Contact sensitization to 5‐chloro‐2‐methyl‐4‐isothiazolin‐3‐one and 2‐methyl‐4‐isothiazolin‐3‐one (MCI/MI) : A European multicentre study. / Menne, T.; Frosch, P. J.; Veien, N. K.; Hannuksela, M.; Björkner, B.; Lachapelle, J. M.; White, I. R.; Vejlsgaard, G.; Schubert, H. J.; Andersen, K. E.; Dooms‐Goossens, A.; Shaw, S.; Wilkinson, J. D.; Camarasa, J. G.; Wahlberg, J. E.; Brandru, F.; Brandao, F. M.; van der Walle, H. B.; Angelini, G.; Thestrup‐Edersen, K.; Burrows, D.; Ducombs, G.; Tosti, Antonella.
In: Contact Dermatitis, Vol. 24, No. 5, 1991, p. 334-341.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Contact sensitization to 5‐chloro‐2‐methyl‐4‐isothiazolin‐3‐one and 2‐methyl‐4‐isothiazolin‐3‐one (MCI/MI)
T2 - A European multicentre study
AU - Menne, T.
AU - Frosch, P. J.
AU - Veien, N. K.
AU - Hannuksela, M.
AU - Björkner, B.
AU - Lachapelle, J. M.
AU - White, I. R.
AU - Vejlsgaard, G.
AU - Schubert, H. J.
AU - Andersen, K. E.
AU - Dooms‐Goossens, A.
AU - Shaw, S.
AU - Wilkinson, J. D.
AU - Camarasa, J. G.
AU - Wahlberg, J. E.
AU - Brandru, F.
AU - Brandao, F. M.
AU - van der Walle, H. B.
AU - Angelini, G.
AU - Thestrup‐Edersen, K.
AU - Burrows, D.
AU - Ducombs, G.
AU - Tosti, Antonella
PY - 1991
Y1 - 1991
N2 - The frequency of positive reactions to 5‐chloro‐2‐methyl‐4‐isothiazolin‐3‐one (MCI/MI) were studied at 22 European cntact dermatitis clinics over a period of 1 year. A total of 4713 patients participated. All the patients were patch tested with nickel sulphate, formaldehyde, paraben‐mix, and MCI/MI 19.4% of the patients had positive patch tests to nickel, making this the most common allergen, 3% of the patients reacted to 100 ppm MCI/MI, while 2.6% reacted to formaldchyde and 1.1% to parabens. There was great variation in the frequency of MCI/MI sensitivity among the 22 centres. MCI/MI contact allergy was most common among women and in patients with facial dermatitis, while it was rarely seen in patients with dermatitis on the lower legs. There were no fluctuations in the number of positive patch tests to MCI/MI on a monthly basis when the results from all centres were combined. 117 of the 141 MCI/MI sensitized patients included in the study were retested 88% had positive patch tests when retested. 101 of the MCI/MI‐sensitive patients participated in a double ‐blind, placebo‐controlled product use test. This test showed that 31% of the MCI/MI‐sensitive patients had a positive reaction to a MCI/MI‐preserved product. Only a few patients reacted to a control product. It is concluded that the preservative MCI/MI is an important new contact allergen.
AB - The frequency of positive reactions to 5‐chloro‐2‐methyl‐4‐isothiazolin‐3‐one (MCI/MI) were studied at 22 European cntact dermatitis clinics over a period of 1 year. A total of 4713 patients participated. All the patients were patch tested with nickel sulphate, formaldehyde, paraben‐mix, and MCI/MI 19.4% of the patients had positive patch tests to nickel, making this the most common allergen, 3% of the patients reacted to 100 ppm MCI/MI, while 2.6% reacted to formaldchyde and 1.1% to parabens. There was great variation in the frequency of MCI/MI sensitivity among the 22 centres. MCI/MI contact allergy was most common among women and in patients with facial dermatitis, while it was rarely seen in patients with dermatitis on the lower legs. There were no fluctuations in the number of positive patch tests to MCI/MI on a monthly basis when the results from all centres were combined. 117 of the 141 MCI/MI sensitized patients included in the study were retested 88% had positive patch tests when retested. 101 of the MCI/MI‐sensitive patients participated in a double ‐blind, placebo‐controlled product use test. This test showed that 31% of the MCI/MI‐sensitive patients had a positive reaction to a MCI/MI‐preserved product. Only a few patients reacted to a control product. It is concluded that the preservative MCI/MI is an important new contact allergen.
KW - 2‐methyl‐4‐isothiazolin‐3‐one
KW - 5‐chloro‐2‐methyl‐4‐isothiazolin‐3‐one
KW - contact allergy
KW - cosmetics
KW - formaldehyde
KW - multicentre study
KW - nickel
KW - parabens
KW - patch testing technique
KW - preservatives
UR - http://www.scopus.com/inward/record.url?scp=0025726971&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025726971&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0536.1991.tb01747.x
DO - 10.1111/j.1600-0536.1991.tb01747.x
M3 - Article
VL - 24
SP - 334
EP - 341
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 5
ER -