TY - JOUR
T1 - Contact dermatitis to palladium
T2 - A study of 2,300 patients
AU - Vincenzi, Colombina
AU - Tosti, Antonella
AU - Guerra, Liliana
AU - Kokelj, Franco
AU - Nobile, Carla
AU - Rivara, Giampiero
AU - Zangrando, Ennio
PY - 1995/6
Y1 - 1995/6
N2 - In the last few years, several investigators have detected a high prevalence of positive patch test reactions to palladium chloride in nickel-sensitized patients. In the majority of these patients, the positive patch tests to palladium chloride had no clinical relavance. The purpose of this study was to evaluate the prevalence and the clinical relevance of the patch test reactions to palladium in patients undergoing patch tests. Two thousand three hundred consecutive patients with allergic contact dermatitis were patch tested with PdCl2 (1% petrolatum) between January 1991 and September 1992. A positive reaction to palladium chloride was detected in 171 of the 2,300 patients (7.4%). One hundred sixty-nine of these 171 patients had a concomitant positive reaction to nickel sulfate. In our opinion, the similarity of the external electronic structure of these two elements is not sufficient by itself to justify a wrong immunologic recognition, whereas a stereochemical analysis of the compound of these two metals could better explain the possible mechanism of this cross-reaction.
AB - In the last few years, several investigators have detected a high prevalence of positive patch test reactions to palladium chloride in nickel-sensitized patients. In the majority of these patients, the positive patch tests to palladium chloride had no clinical relavance. The purpose of this study was to evaluate the prevalence and the clinical relevance of the patch test reactions to palladium in patients undergoing patch tests. Two thousand three hundred consecutive patients with allergic contact dermatitis were patch tested with PdCl2 (1% petrolatum) between January 1991 and September 1992. A positive reaction to palladium chloride was detected in 171 of the 2,300 patients (7.4%). One hundred sixty-nine of these 171 patients had a concomitant positive reaction to nickel sulfate. In our opinion, the similarity of the external electronic structure of these two elements is not sufficient by itself to justify a wrong immunologic recognition, whereas a stereochemical analysis of the compound of these two metals could better explain the possible mechanism of this cross-reaction.
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U2 - 10.1016/1046-199X(95)90108-6
DO - 10.1016/1046-199X(95)90108-6
M3 - Article
AN - SCOPUS:0029012920
VL - 6
SP - 110
EP - 112
JO - Dermatitis
JF - Dermatitis
SN - 1710-3568
IS - 2
ER -