Construction of a physical model of the human carotid artery based upon in vivo magnetic resonance images

R. V. Yedavalli, F. Loth, A. Yardimci, W. F. Pritchard, J. N. Oshinski, L. Sadler, F. Charbel, N. Alperin

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

A method is described for construction of an in vitro flow model based on in vivo measurements of the lumen geometry of the human carotid bifurcation. A large-scale physical model of the vessel lumen was constructed using fused deposition modeling (a rapid prototyping technique) based on magnetic resonance (MR) images of the carotid bifurcation acquired in a healthy volunteer. The lumen negative was then used to construct a flow model for experimental studies that examined the hemodynamic environment of subject-specific geometry and flow conditions. The physical model also supplements physician insight into the three-dimensional geometry of the arterial segment, complementing the two-dimensional images obtained by MR. Study of the specific geometry and flow conditions in patients with vascular disease may contribute to our understanding of the relationship between their hemodynamic environment and conditions that lead to the development and progression of arterial disease.

Original languageEnglish (US)
Pages (from-to)372-376
Number of pages5
JournalJournal of biomechanical engineering
Volume123
Issue number4
DOIs
StatePublished - Sep 21 2001

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Construction of a physical model of the human carotid artery based upon in vivo magnetic resonance images'. Together they form a unique fingerprint.

  • Cite this

    Yedavalli, R. V., Loth, F., Yardimci, A., Pritchard, W. F., Oshinski, J. N., Sadler, L., Charbel, F., & Alperin, N. (2001). Construction of a physical model of the human carotid artery based upon in vivo magnetic resonance images. Journal of biomechanical engineering, 123(4), 372-376. https://doi.org/10.1115/1.1385845