Abstract
Objective: To evaluate the maternal and neonatal outcome of pregnancies after preterm premature rupture of membranes (PPROM) between 18 and 23 weeks of gestation. Study design: We performed a retrospective analysis of all deliveries at the University of Miami/Jackson Memorial Hospital after PPROM between 18 and 23 weeks of gestation from January 1997 to December 1999. All patients who delivered within 12 h of rupture of membranes were excluded. We further analyzed the data by dividing the patients into three groups based on the gestational age at which PPROM occurred as follows: (1) 18-19 weeks, (2) 20-21 weeks and (3) 22-23 weeks. For statistical analysis we combined two groups 18-19 weeks and 20-21 weeks. Results: A total of 66 singleton pregnancies were included in our study. Median overall latency period until delivery was 62 h (range 12-654) with significantly prolonged latency at 22-23 weeks gestation in comparison to earlier gestation. Maternal complications were chorioamnionitis (n = 19), placental abruption (n = 3), retained placenta (n = 6) and postpartum hemorrhage (n = 5). Twenty fetuses were born alive (none between 18 and 19 weeks, 2 between 20 and 21 weeks and 18 between 22 and 23 weeks). These infants remained in the nursery between 1 and 555 days (median 106 days). A total of 12 infants were discharged home alive (1 between 20 and 21 weeks, 11 between 22 and 23 weeks). All surviving infants suffered at least one major neonatal complication. Conclusion: Conservative management of PPROM prior to 21 weeks of gestation was associated with very poor pregnancy outcome in our study. Although survival improved significantly after 22 weeks, all infants suffered major neonatal morbidity.
| Original language | English |
|---|---|
| Pages (from-to) | 119-124 |
| Number of pages | 6 |
| Journal | European Journal of Obstetrics Gynecology and Reproductive Biology |
| Volume | 128 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Sep 1 2006 |
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Keywords
- Conservative management
- Preterm premature rupture of membranes
- Second trimester
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Reproductive Medicine
Cite this
Conservative management of preterm premature rupture of membranes between 18 and 23 weeks of gestation-Maternal and neonatal outcome. / Verma, Usha; Goharkhay, Nima; Beydoun, Samir.
In: European Journal of Obstetrics Gynecology and Reproductive Biology, Vol. 128, No. 1-2, 01.09.2006, p. 119-124.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Conservative management of preterm premature rupture of membranes between 18 and 23 weeks of gestation-Maternal and neonatal outcome
AU - Verma, Usha
AU - Goharkhay, Nima
AU - Beydoun, Samir
PY - 2006/9/1
Y1 - 2006/9/1
N2 - Objective: To evaluate the maternal and neonatal outcome of pregnancies after preterm premature rupture of membranes (PPROM) between 18 and 23 weeks of gestation. Study design: We performed a retrospective analysis of all deliveries at the University of Miami/Jackson Memorial Hospital after PPROM between 18 and 23 weeks of gestation from January 1997 to December 1999. All patients who delivered within 12 h of rupture of membranes were excluded. We further analyzed the data by dividing the patients into three groups based on the gestational age at which PPROM occurred as follows: (1) 18-19 weeks, (2) 20-21 weeks and (3) 22-23 weeks. For statistical analysis we combined two groups 18-19 weeks and 20-21 weeks. Results: A total of 66 singleton pregnancies were included in our study. Median overall latency period until delivery was 62 h (range 12-654) with significantly prolonged latency at 22-23 weeks gestation in comparison to earlier gestation. Maternal complications were chorioamnionitis (n = 19), placental abruption (n = 3), retained placenta (n = 6) and postpartum hemorrhage (n = 5). Twenty fetuses were born alive (none between 18 and 19 weeks, 2 between 20 and 21 weeks and 18 between 22 and 23 weeks). These infants remained in the nursery between 1 and 555 days (median 106 days). A total of 12 infants were discharged home alive (1 between 20 and 21 weeks, 11 between 22 and 23 weeks). All surviving infants suffered at least one major neonatal complication. Conclusion: Conservative management of PPROM prior to 21 weeks of gestation was associated with very poor pregnancy outcome in our study. Although survival improved significantly after 22 weeks, all infants suffered major neonatal morbidity.
AB - Objective: To evaluate the maternal and neonatal outcome of pregnancies after preterm premature rupture of membranes (PPROM) between 18 and 23 weeks of gestation. Study design: We performed a retrospective analysis of all deliveries at the University of Miami/Jackson Memorial Hospital after PPROM between 18 and 23 weeks of gestation from January 1997 to December 1999. All patients who delivered within 12 h of rupture of membranes were excluded. We further analyzed the data by dividing the patients into three groups based on the gestational age at which PPROM occurred as follows: (1) 18-19 weeks, (2) 20-21 weeks and (3) 22-23 weeks. For statistical analysis we combined two groups 18-19 weeks and 20-21 weeks. Results: A total of 66 singleton pregnancies were included in our study. Median overall latency period until delivery was 62 h (range 12-654) with significantly prolonged latency at 22-23 weeks gestation in comparison to earlier gestation. Maternal complications were chorioamnionitis (n = 19), placental abruption (n = 3), retained placenta (n = 6) and postpartum hemorrhage (n = 5). Twenty fetuses were born alive (none between 18 and 19 weeks, 2 between 20 and 21 weeks and 18 between 22 and 23 weeks). These infants remained in the nursery between 1 and 555 days (median 106 days). A total of 12 infants were discharged home alive (1 between 20 and 21 weeks, 11 between 22 and 23 weeks). All surviving infants suffered at least one major neonatal complication. Conclusion: Conservative management of PPROM prior to 21 weeks of gestation was associated with very poor pregnancy outcome in our study. Although survival improved significantly after 22 weeks, all infants suffered major neonatal morbidity.
KW - Conservative management
KW - Preterm premature rupture of membranes
KW - Second trimester
UR - http://www.scopus.com/inward/record.url?scp=33748204474&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748204474&partnerID=8YFLogxK
U2 - 10.1016/j.ejogrb.2005.12.005
DO - 10.1016/j.ejogrb.2005.12.005
M3 - Article
C2 - 16446024
AN - SCOPUS:33748204474
VL - 128
SP - 119
EP - 124
JO - European Journal of Obstetrics and Gynecology and Reproductive Biology
JF - European Journal of Obstetrics and Gynecology and Reproductive Biology
SN - 0028-2243
IS - 1-2
ER -