Conservation of hearing and protection of hair cells in cochlear implant patients' with residual hearing

Esperanza Bas, Christine T. Dinh, Carolyn Garnham, Marek Polak, Thomas R. Van de Water

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

This review covers the molecular mechanisms involved in hair cell and hearing losses which can result from trauma generated during the process of cochlear implantation and the contributions of both the intrinsic and extrinsic cell death signaling pathways in producing these trauma/inflammation induced losses. Application of soft surgical techniques to conserve hearing and protect auditory sensory cells during the process of cochlear implantation surgery and insertion of the electrode array during the process of cochlear implantation are reviewed and discussed. The role of drug therapy and mode of drug delivery for the conservation of a cochlear implant patient's residual hearing is presented and discussed.

Original languageEnglish (US)
Pages (from-to)1909-1927
Number of pages19
JournalAnatomical Record
Volume295
Issue number11
DOIs
StatePublished - Nov 1 2012

Keywords

  • Cochlear implantation
  • Hair cell protection
  • Hearing conservation
  • Inflammation
  • Otoprotective drugs
  • Oxidative stress
  • Programmed cell death
  • Trauma

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Ecology, Evolution, Behavior and Systematics
  • Biotechnology

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