Consensus Report by the Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplantation Consortium Joint Working Committees on Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents, Part 3: Focus on Cardiorespiratory Dysfunction, Infections, Liver Dysfunction, and Delirium

Nadia Ovchinsky, Warren Frazier, Jeffery J. Auletta, Christopher C. Dvorak, Monica Ardura, Enkyung Song, Jennifer McArthur, Asumthia Jeyapalan, Robert Tamburro, Kris M. Mahadeo, Chani Traube, Christine N. Duncan, Rajinder P.S. Bajwa

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Some patients with veno-occlusive disease (VOD) have multiorgan dysfunction, and multiple teams are involved in their daily care in the pediatric intensive care unit. Cardiorespiratory dysfunction is critical in these patients, requiring immediate action. The decision of whether to use a noninvasive or an invasive ventilation strategy may be difficult in the setting of mucositis or other comorbidities in patients with VOD. Similarly, monitoring of organ functions may be very challenging in these patients, who may have fulminant hepatic failure with or without hepatic encephalopathy complicated by delirium and/or infections. In this final guideline of our series on supportive care in patients with VOD, we address some of these questions and provide evidence-based recommendations on behalf of the Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplantation Consortium Joint Working Committees.

Original languageEnglish (US)
Pages (from-to)207-218
Number of pages12
JournalBiology of Blood and Marrow Transplantation
Volume24
Issue number2
DOIs
StatePublished - Feb 2018

Keywords

  • Cardiorespiratory dysfunction
  • Delirium
  • Fulminant hepatic failure
  • Infections
  • Multiorgan dysfunction
  • Veno-occlusive disease

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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