Consensus Report by the Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplant Consortium Joint Working Committees on Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents: Part 2—Focus on Ascites, Fluid and Electrolytes, Renal, and Transfusion Issues

Kris M. Mahadeo, Jennifer McArthur, Roberta H. Adams, Mohamed Radhi, Joseph Angelo, Asumthia Jeyapalan, Kathleen Nicol, Leon Su, Hanna Rabi, Jeffery J. Auletta, Vinita Pai, Christine N. Duncan, Robert Tamburro, Christopher C. Dvorak, Rajinder P.S. Bajwa

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Even though hepatic veno-occlusive disease (VOD) is a potentially fatal complication of hematopoietic cell transplantation (HCT), there is paucity of research on the management of associated multiorgan dysfunction. To help provide standardized care for the management of these patients, the HCT Subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators and the Supportive Care Committee of the Pediatric Blood and Marrow Transplant Consortium, collaborated to develop evidence-based consensus guidelines. After conducting an extensive literature search, in part 2 of this series we discuss the management of fluids and electrolytes, renal dysfunction; ascites, pleural effusion, and transfusion and coagulopathy issues in patients with VOD. We consider the available evidence using the GRADE criteria.

Original languageEnglish (US)
Pages (from-to)2023-2033
Number of pages11
JournalBiology of Blood and Marrow Transplantation
Volume23
Issue number12
DOIs
StatePublished - Dec 2017

Keywords

  • AKI
  • Ascites
  • Multiorgan dysfunction
  • Paracentesis
  • Pleural effusion
  • Renal failure
  • SOS
  • Thrombocytopenia
  • VOD

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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