Consensus Guidelines for Delineation of Clinical Target Volume for Intensity-Modulated Pelvic Radiotherapy in Postoperative Treatment of Endometrial and Cervical Cancer

William Small, Loren K. Mell, Penny Anderson, Carien Creutzberg, Jennifer De Los Santos, David Gaffney, Anuja Jhingran, Lorraine Portelance, Tracey Schefter, Revathy Iyer, Mahesh Varia, Kathryn Winter, Arno J. Mundt

Research output: Contribution to journalArticle

225 Citations (Scopus)

Abstract

Purpose: To develop an atlas of the clinical target volume (CTV) definitions for postoperative radiotherapy of endometrial and cervical cancer to be used for planning pelvic intensity-modulated radiotherapy. Methods and Materials: The Radiation Therapy Oncology Group led an international collaberation of cooperative groups in the development of the atlas. The groups included the Radiation Therapy Oncology Group, Gynecologic Oncology Group, National Cancer Institute of Canada, European Society of Therapeutic Radiology and Oncology, and American College of Radiology Imaging Network. The members of the group were asked by questionnaire to define the areas that were to be included in the CTV and to outline theses areas on individual computed tomography images. The initial formulation of the group began in late 2004 and culminated with a formal consensus conference in June 2005. Results: The committee achieved a consensus CTV definition for postoperative therapy for endometrial and cervical cancer. The CTV should include the common, external, and internal iliac lymph node regions. The upper 3.0 cm of the vagina and paravaginal soft tissue lateral to the vagina should also be included. For patients with cervical cancer, or endometrial cancer with cervical stromal invasion, it is also recommended that the CTV include the presacral lymph node region. Conclusion: This report serves as an international template for the definition of the CTV for postoperative intensity-modulated radiotherapy for endometrial and cervical cancer.

Original languageEnglish
Pages (from-to)428-434
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume71
Issue number2
DOIs
StatePublished - Jun 1 2008
Externally publishedYes

Fingerprint

Intensity-Modulated Radiotherapy
delineation
Endometrial Neoplasms
Uterine Cervical Neoplasms
Radiation Oncology
radiation therapy
cancer
Guidelines
Radiotherapy
Atlases
Vagina
Lymph Nodes
radiology
lymphatic system
National Cancer Institute (U.S.)
Therapeutics
Radiology
Canada
Tomography
theses

Keywords

  • Adjuvant therapy
  • Cervical cancer
  • Endometrial cancer
  • Intensity-modulated radiotherapy
  • Pelvic radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Consensus Guidelines for Delineation of Clinical Target Volume for Intensity-Modulated Pelvic Radiotherapy in Postoperative Treatment of Endometrial and Cervical Cancer. / Small, William; Mell, Loren K.; Anderson, Penny; Creutzberg, Carien; De Los Santos, Jennifer; Gaffney, David; Jhingran, Anuja; Portelance, Lorraine; Schefter, Tracey; Iyer, Revathy; Varia, Mahesh; Winter, Kathryn; Mundt, Arno J.

In: International Journal of Radiation Oncology Biology Physics, Vol. 71, No. 2, 01.06.2008, p. 428-434.

Research output: Contribution to journalArticle

Small, William ; Mell, Loren K. ; Anderson, Penny ; Creutzberg, Carien ; De Los Santos, Jennifer ; Gaffney, David ; Jhingran, Anuja ; Portelance, Lorraine ; Schefter, Tracey ; Iyer, Revathy ; Varia, Mahesh ; Winter, Kathryn ; Mundt, Arno J. / Consensus Guidelines for Delineation of Clinical Target Volume for Intensity-Modulated Pelvic Radiotherapy in Postoperative Treatment of Endometrial and Cervical Cancer. In: International Journal of Radiation Oncology Biology Physics. 2008 ; Vol. 71, No. 2. pp. 428-434.
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AU - Small, William

AU - Mell, Loren K.

AU - Anderson, Penny

AU - Creutzberg, Carien

AU - De Los Santos, Jennifer

AU - Gaffney, David

AU - Jhingran, Anuja

AU - Portelance, Lorraine

AU - Schefter, Tracey

AU - Iyer, Revathy

AU - Varia, Mahesh

AU - Winter, Kathryn

AU - Mundt, Arno J.

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N2 - Purpose: To develop an atlas of the clinical target volume (CTV) definitions for postoperative radiotherapy of endometrial and cervical cancer to be used for planning pelvic intensity-modulated radiotherapy. Methods and Materials: The Radiation Therapy Oncology Group led an international collaberation of cooperative groups in the development of the atlas. The groups included the Radiation Therapy Oncology Group, Gynecologic Oncology Group, National Cancer Institute of Canada, European Society of Therapeutic Radiology and Oncology, and American College of Radiology Imaging Network. The members of the group were asked by questionnaire to define the areas that were to be included in the CTV and to outline theses areas on individual computed tomography images. The initial formulation of the group began in late 2004 and culminated with a formal consensus conference in June 2005. Results: The committee achieved a consensus CTV definition for postoperative therapy for endometrial and cervical cancer. The CTV should include the common, external, and internal iliac lymph node regions. The upper 3.0 cm of the vagina and paravaginal soft tissue lateral to the vagina should also be included. For patients with cervical cancer, or endometrial cancer with cervical stromal invasion, it is also recommended that the CTV include the presacral lymph node region. Conclusion: This report serves as an international template for the definition of the CTV for postoperative intensity-modulated radiotherapy for endometrial and cervical cancer.

AB - Purpose: To develop an atlas of the clinical target volume (CTV) definitions for postoperative radiotherapy of endometrial and cervical cancer to be used for planning pelvic intensity-modulated radiotherapy. Methods and Materials: The Radiation Therapy Oncology Group led an international collaberation of cooperative groups in the development of the atlas. The groups included the Radiation Therapy Oncology Group, Gynecologic Oncology Group, National Cancer Institute of Canada, European Society of Therapeutic Radiology and Oncology, and American College of Radiology Imaging Network. The members of the group were asked by questionnaire to define the areas that were to be included in the CTV and to outline theses areas on individual computed tomography images. The initial formulation of the group began in late 2004 and culminated with a formal consensus conference in June 2005. Results: The committee achieved a consensus CTV definition for postoperative therapy for endometrial and cervical cancer. The CTV should include the common, external, and internal iliac lymph node regions. The upper 3.0 cm of the vagina and paravaginal soft tissue lateral to the vagina should also be included. For patients with cervical cancer, or endometrial cancer with cervical stromal invasion, it is also recommended that the CTV include the presacral lymph node region. Conclusion: This report serves as an international template for the definition of the CTV for postoperative intensity-modulated radiotherapy for endometrial and cervical cancer.

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KW - Cervical cancer

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KW - Intensity-modulated radiotherapy

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