Conjunctival Intraepithelial Neoplasia with Mucoepidermoid Differentiation: A Case Report of a Subtle Lesion

Madhura G. Joag, Anita Gupta, Anat Galor, Sander R. Dubovy, Jose Antonio Bermudez-Magner, Jianhua Wang, Carol L. Karp

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Objective: To describe the clinical presentation, diagnostic imaging, and treatment options of conjunctival intraepithelial neoplasia (CIN) with mucoepidermoid differentiation, an in situ stage of mucoepidermoid carcinoma of the conjunctiva (MCC). Results: We report the case of an 86-year-old man presenting with a subtle limbal lesion that had only mild erythema and elevation. Based on a few atypical clinical features and an abnormal ultrahigh-resolution optical coherence tomography (UHR OCT), an incisional biopsy was performed revealing CIN with mucoepidermoid differentiation. Treatment involved aggressive surgical excision. No evidence of recurrence was noted in the 5 years of follow-up. Conclusion: MCC is an aggressive tumor that has a tendency to be invasive and recur after treatment. Therefore, early diagnosis and treatment is critical. CIN with mucoepidermoid differentiation may represent the earliest stage of MCC. It can present subtly, with a clinical resemblance to benign and less aggressive ocular surface lesions. Imaging with UHR OCT may be helpful to detect early neoplasia. A high level of suspicion must be maintained when evaluating potential ocular surface tumors.

Original languageEnglish (US)
Pages (from-to)278-282
Number of pages5
JournalOcular Oncology and Pathology
Issue number4
StatePublished - Jun 1 2015


  • Conjunctival intraepithelial neoplasia
  • Imaging
  • Mucoepidermoid differentiation
  • Neoplasia
  • Optical coherence tomography

ASJC Scopus subject areas

  • Nursing(all)


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