Conjunctival cytologic features of primary Sjogren's syndrome

S. C. Pflugfelder, A. J W Huang, William J Feuer, P. T. Chuchovski, I. C. Pereira, S. C G Tseng

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Abstract

To determine whether there are specific cytologic features associated with primary Sjogren's syndrome (SS), the authors evaluated impression cytology specimens from three conjunctival sites (temporal bulbar [TB], inferior bulbar [IB], and inferior tarsal [IT]) from 38 SS eyes, 34 eyes of aqueous tear-deficient patients without SS, 35 eyes of seborrheic blepharitis patients, and 17 eyes of normal controls in a masked fashion. The following features were observed more frequently in SS eyes than in the eyes of the other groups: squamous metaplasia of the TB and IB (P <0.05), extensive (> 75%) goblet cell loss of the TB (P <0.05), mucous aggregates of the bulbar conjunctiva (P <0.05), and inflammatory cells intercalated with epithelial cells on the IT conjunctiva (P <0.06). The conjunctival inflammatory cell infiltrate correlated with the presence of extensive squamous metaplasia (P <0.01) in SS specimens. The inflammatory cells on the IT conjunctival epithelium were found to consist predominantly of T-lymphocytes by immunofluorescent staining of cytologic specimens from six eyes. Based on these findings, the authors speculated that conjunctival squamous metaplasia, in addition to aqueous tear deficiency, may be due to primary involvement of the dysfunctional immune system of SS.

Original languageEnglish (US)
Pages (from-to)985-991
Number of pages7
JournalOphthalmology
Volume97
Issue number8
StatePublished - 1990

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Sjogren's Syndrome
Metaplasia
Conjunctiva
Tears
Blepharitis
Goblet Cells
Cell Biology
Immune System
Epithelium
Epithelial Cells
Staining and Labeling
T-Lymphocytes

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Pflugfelder, S. C., Huang, A. J. W., Feuer, W. J., Chuchovski, P. T., Pereira, I. C., & Tseng, S. C. G. (1990). Conjunctival cytologic features of primary Sjogren's syndrome. Ophthalmology, 97(8), 985-991.

Conjunctival cytologic features of primary Sjogren's syndrome. / Pflugfelder, S. C.; Huang, A. J W; Feuer, William J; Chuchovski, P. T.; Pereira, I. C.; Tseng, S. C G.

In: Ophthalmology, Vol. 97, No. 8, 1990, p. 985-991.

Research output: Contribution to journalArticle

Pflugfelder, SC, Huang, AJW, Feuer, WJ, Chuchovski, PT, Pereira, IC & Tseng, SCG 1990, 'Conjunctival cytologic features of primary Sjogren's syndrome', Ophthalmology, vol. 97, no. 8, pp. 985-991.
Pflugfelder SC, Huang AJW, Feuer WJ, Chuchovski PT, Pereira IC, Tseng SCG. Conjunctival cytologic features of primary Sjogren's syndrome. Ophthalmology. 1990;97(8):985-991.
Pflugfelder, S. C. ; Huang, A. J W ; Feuer, William J ; Chuchovski, P. T. ; Pereira, I. C. ; Tseng, S. C G. / Conjunctival cytologic features of primary Sjogren's syndrome. In: Ophthalmology. 1990 ; Vol. 97, No. 8. pp. 985-991.
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