Conjugated quantum dots inhibit the amyloid β(1-42) fibrillation process

Roger M. Leblanc, Garima Thakur, Miodrag Micic, Yuehai Yang, Wenzhi Li, Dania Movia, Silvia Giordani, Hongzhou Zhang

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Nanoparticles have enormous potential in diagnostic and therapeutic studies. We have demonstrated that the amyloid beta mixed with and conjugated to dihydrolipoic acid- (DHLA) capped CdSe/ZnS quantum dots (QDs) of size approximately 2.5nm can be used to reduce the fibrillation process. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) were used as tools for analysis of fibrillation. There is a significant change in morphology of fibrils when amyloid β(1-42) (Aβ (1-42)) is mixed or conjugated to the QDs. The length and the width of the fibrils vary under modified conditions. Thioflavin T (ThT) fluorescence supports the decrease in fibril formation in presence of DHLA-capped QDs.

Original languageEnglish (US)
Article number502386
JournalInternational Journal of Alzheimer's Disease
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Aging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Behavioral Neuroscience

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