Conjugant addition and free-radical crosslinking to produce cell-adhesive materials

Donald L. Elbert, Jeffrey A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In tissue engineering, several important factors govern the quality of cellular integration within a biomaterial. A new protocol for producing materials containing biomolecules is developed. The endothelization of these materials within the artery is explored and a chemical scheme to achieve this goal is described using both conjugate addition and free radical reactions with an acrylate group. The reaction of synthesized of cell adhesive peptides with polyethylene glycol occurred rapidly in buffered water, and the biomolecules were incorporated within the gel in an active form.

Original languageEnglish (US)
Title of host publicationAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
PublisherACS
Pages991
Number of pages1
Volume41
Edition1
StatePublished - Mar 2000
Externally publishedYes
EventThe San Francisco Meeting - San Francisco, CA, USA
Duration: Mar 26 2000Mar 31 2000

Other

OtherThe San Francisco Meeting
CitySan Francisco, CA, USA
Period3/26/003/31/00

Fingerprint

Biomolecules
Free radicals
Crosslinking
Free Radicals
Adhesives
Free radical reactions
Biocompatible Materials
Tissue engineering
Biomaterials
Peptides
Polyethylene glycols
Gels
Water
acrylic acid

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

Elbert, D. L., & Hubbell, J. A. (2000). Conjugant addition and free-radical crosslinking to produce cell-adhesive materials. In American Chemical Society, Polymer Preprints, Division of Polymer Chemistry (1 ed., Vol. 41, pp. 991). ACS.

Conjugant addition and free-radical crosslinking to produce cell-adhesive materials. / Elbert, Donald L.; Hubbell, Jeffrey A.

American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. Vol. 41 1. ed. ACS, 2000. p. 991.

Research output: Chapter in Book/Report/Conference proceedingChapter

Elbert, DL & Hubbell, JA 2000, Conjugant addition and free-radical crosslinking to produce cell-adhesive materials. in American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 1 edn, vol. 41, ACS, pp. 991, The San Francisco Meeting, San Francisco, CA, USA, 3/26/00.
Elbert DL, Hubbell JA. Conjugant addition and free-radical crosslinking to produce cell-adhesive materials. In American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 1 ed. Vol. 41. ACS. 2000. p. 991
Elbert, Donald L. ; Hubbell, Jeffrey A. / Conjugant addition and free-radical crosslinking to produce cell-adhesive materials. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. Vol. 41 1. ed. ACS, 2000. pp. 991
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