Conjugant addition and free-radical crosslinking to produce cell-adhesive materials

Donald L. Elbert, Jeffrey A. Hubbell

Research output: Contribution to journalConference article

Abstract

In tissue engineering, several important factors govern the quality of cellular integration within a biomaterial. A new protocol for producing materials containing biomolecules is developed. The endothelization of these materials within the artery is explored and a chemical scheme to achieve this goal is described using both conjugate addition and free radical reactions with an acrylate group. The reaction of synthesized of cell adhesive peptides with polyethylene glycol occurred rapidly in buffered water, and the biomolecules were incorporated within the gel in an active form.

Original languageEnglish (US)
Number of pages1
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume41
Issue number1
StatePublished - Mar 1 2000
EventThe San Francisco Meeting - San Francisco, CA, USA
Duration: Mar 26 2000Mar 31 2000

ASJC Scopus subject areas

  • Polymers and Plastics

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