Congenital uterine anomalies and adverse pregnancy outcomes

Meiling Hua, Anthony O. Odibo, Ryan E. Longman, George A. MacOnes, Kimberly A. Roehl, Alison G. Cahill

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Objective: We sought to estimate whether the presence of a maternal uterine anomaly is associated with adverse pregnancy outcomes. Study Design: This retrospective cohort study included singleton pregnancies undergoing routine anatomic survey from 1990 through 2008 at a major tertiary care medical center. Pregnancies with a diagnosis of uterine anomaly (uterine septum, unicornuate uterus, bicornuate uterus, uterine didelphys) were compared to those with normal anatomy. Primary outcomes of interest were spontaneous preterm birth (PTB), breech presentation, and cesarean delivery. Results: The presence of an anomaly was associated with PTB <34 weeks (adjusted odds ratio [aOR], 7.4; 95% confidence interval [CI], 4.811.4; P <.01), PTB <37 weeks (aOR, 5.9, 95% CI, 4.38.1; P <.01), primary nonbreech cesarean delivery (aOR, 2.6; 95% CI, 1.74.0; P <.01), preterm premature rupture of membranes (aOR, 3.2; 95% CI, 1.85.6; P <.01), and breech presentation (aOR, 8.6; 95% CI, 6.212.0; P <.01). Conclusion: Women with a uterine anomaly are at risk for PTB, highlighting an at-risk population that needs additional study for possible interventions for PTB prevention.

Original languageEnglish (US)
Pages (from-to)558.e1-558.e5
JournalAmerican journal of obstetrics and gynecology
Issue number6
StatePublished - Dec 2011
Externally publishedYes


  • adverse pregnancy outcomes
  • bicornuate
  • didelphys
  • mllerian anomalies
  • preterm birth
  • septum
  • unicornuate

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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