Congenital syphilis: The University of Miami/ Jackson Memorial Medical Center experience, 1986-1988

Jean M. Ricci, Rita M. Fojaco, Mary Jo O'Sullivan

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Between January 1, 1986 and July 1, 1988, 56 cases of congenital syphilis were identified at the University of Miami/Jackson Memorial Medical Center. The overall rate was 18.4 cases per 10,000 births, with a threefold increase found from 1986 to 1988. A case-control study using matched pairs was done to identify differences in maternal demographics and pregnancy outcome. Congenital syphilis case mothers were predominantly black American women who lacked prenatal care (67%) and who were substance abusers (71%) significantly more often than their matched controls (P < .005). Three cases of seroconversion in pregnancy were identified. Failure to screen or inappropriate treatment occurred in four patients. Seven women were treated during pregnancy: Five received benzathine penicillin G for 3 consecutive weeks and two received erythromycin. All treated patients presented for initial care in the late second or third trimester. Thirty-seven infants (66%) were live-born and 19 (34%) were stillborn. Preterm labor and premature rupture of the membranes were significantly more common in infected pregnancies than in controls (P < .005). Liveborn case infants had significantly lower birth weights than controls (P < .005), with 21% of case infants growth-retarded. Seven neonatal deaths and one infant death occurred. The resultant perinatal mortality rate from congenital syphilis in this series was 464 per 1000.

Original languageEnglish
Pages (from-to)687-693
Number of pages7
JournalObstetrics and Gynecology
Volume74
Issue number5
StatePublished - Nov 1 1989

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Congenital Syphilis
Pregnancy
Mothers
Penicillin G Benzathine
Prenatal Care
Premature Obstetric Labor
Perinatal Mortality
Third Pregnancy Trimester
Second Pregnancy Trimester
Erythromycin
Pregnancy Outcome
Contraception
Birth Weight
Case-Control Studies
Demography
Parturition
Mortality
Growth
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Congenital syphilis : The University of Miami/ Jackson Memorial Medical Center experience, 1986-1988. / Ricci, Jean M.; Fojaco, Rita M.; O'Sullivan, Mary Jo.

In: Obstetrics and Gynecology, Vol. 74, No. 5, 01.11.1989, p. 687-693.

Research output: Contribution to journalArticle

Ricci, Jean M. ; Fojaco, Rita M. ; O'Sullivan, Mary Jo. / Congenital syphilis : The University of Miami/ Jackson Memorial Medical Center experience, 1986-1988. In: Obstetrics and Gynecology. 1989 ; Vol. 74, No. 5. pp. 687-693.
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