Purpose. Although chronic myelogenous leukemia (CML) is considered an aquired hematologic disease, the Philadelphia-Chromosome, a gene translocation from chromosome 9 to chromosome 22 plays a major role in the pathogenesis as it is present in more than 90% of patients. Genetic defects, or maternal rubella infection, irradiation, and drugs during the first trimenon of pregnancy, may cause cataracta centralis pulverulenta, still the etiology remains unclear in the majority of cases Methods. 75 patients (32 female / 43 male) with CML underwent full ophthalmologic examination (Visual acuity, Goldmann applanation tonometry, biomicroscopy, and funduscopy) before bone marrow transplantation. Additionally, the anterior segment of the eye was assessed with a Topcon SL-45 Scheimpflug camera with integrated image processing device. Contrast sensitivity was detected under standard conditions with Pelli-Robson charts. Results. 73 patients revealed clear lenses before bone marrow transplantation, but two female patients (2,7% of all, 6,3% of females) showed cataracta centralis pulverulenta. Scheimpflug images of these findings will be demonstrated. Conclusions. The prevalence of congenital central nuclear cataract in our patients with CML is significantly increased (expected prevalence / observed prevalence). A common defect in both diseases may be taken into consideration as a tessera of CML etiology.
|Original language||English (US)|
|Journal||Investigative Ophthalmology and Visual Science|
|State||Published - Feb 15 1996|
ASJC Scopus subject areas
- Sensory Systems
- Cellular and Molecular Neuroscience