Conformal coating process refinement and materials optimization improves the insulin secretion of encapsulated islets

Aaron A. Stock, Diana Velluto, Alice Tomei

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose. Type 1 diabetes (T1D) results in the T cell-mediated destruction of the insulin-producing β cells in the pancreas. β cell replacement by way of donor islet transplantation would allay the problems associated with the disease but requires systemic immunosuppression for graft function and survival. Due to immune suppression, islet transplantation is only indicated for a fraction of patients with T1D. Islet encapsulation strives to protect the donor tissue by preventing direct contact with host immune cells. While such strategies have exhibited safety in clinical trials, long-term efficacy remains a lofty goal that is subverted by the large graft volumes, limited access to well vascularized sites, and increased barrier to diffusion associated with traditional microencapsulation. Conformal coating minimizes capsule thickness and graft volume, representing the next generation of encapsulated islet products (Fig. 1). Here, we hypothesize that the post-conformal coating viability and glucose-stimulated insulin secretion (GSIS) performance of islets may be increased by optimizing process parameters, materials, and recovery procedures associate with this platform.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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    Stock, A. A., Velluto, D., & Tomei, A. (2019). Conformal coating process refinement and materials optimization improves the insulin secretion of encapsulated islets. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.