Abstract
Statement of Purpose. Type 1 diabetes (T1D) results in the T cell-mediated destruction of the insulin-producing β cells in the pancreas. β cell replacement by way of donor islet transplantation would allay the problems associated with the disease but requires systemic immunosuppression for graft function and survival. Due to immune suppression, islet transplantation is only indicated for a fraction of patients with T1D. Islet encapsulation strives to protect the donor tissue by preventing direct contact with host immune cells. While such strategies have exhibited safety in clinical trials, long-term efficacy remains a lofty goal that is subverted by the large graft volumes, limited access to well vascularized sites, and increased barrier to diffusion associated with traditional microencapsulation. Conformal coating minimizes capsule thickness and graft volume, representing the next generation of encapsulated islet products (Fig. 1). Here, we hypothesize that the post-conformal coating viability and glucose-stimulated insulin secretion (GSIS) performance of islets may be increased by optimizing process parameters, materials, and recovery procedures associate with this platform.
| Original language | English (US) |
|---|---|
| Title of host publication | Society for Biomaterials Annual Meeting and Exposition 2019 |
| Subtitle of host publication | The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting |
| Publisher | Society for Biomaterials |
| Number of pages | 1 |
| ISBN (Electronic) | 9781510883901 |
| State | Published - Jan 1 2019 |
| Event | 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States Duration: Apr 3 2019 → Apr 6 2019 |
Publication series
| Name | Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium |
|---|---|
| Volume | 40 |
| ISSN (Print) | 1526-7547 |
Conference
| Conference | 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence |
|---|---|
| Country | United States |
| City | Seattle |
| Period | 4/3/19 → 4/6/19 |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Biotechnology
- Biomaterials
- Materials Chemistry
Cite this
Conformal coating process refinement and materials optimization improves the insulin secretion of encapsulated islets. / Stock, Aaron A.; Velluto, Diana; Tomei, Alice.
Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Conformal coating process refinement and materials optimization improves the insulin secretion of encapsulated islets
AU - Stock, Aaron A.
AU - Velluto, Diana
AU - Tomei, Alice
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Statement of Purpose. Type 1 diabetes (T1D) results in the T cell-mediated destruction of the insulin-producing β cells in the pancreas. β cell replacement by way of donor islet transplantation would allay the problems associated with the disease but requires systemic immunosuppression for graft function and survival. Due to immune suppression, islet transplantation is only indicated for a fraction of patients with T1D. Islet encapsulation strives to protect the donor tissue by preventing direct contact with host immune cells. While such strategies have exhibited safety in clinical trials, long-term efficacy remains a lofty goal that is subverted by the large graft volumes, limited access to well vascularized sites, and increased barrier to diffusion associated with traditional microencapsulation. Conformal coating minimizes capsule thickness and graft volume, representing the next generation of encapsulated islet products (Fig. 1). Here, we hypothesize that the post-conformal coating viability and glucose-stimulated insulin secretion (GSIS) performance of islets may be increased by optimizing process parameters, materials, and recovery procedures associate with this platform.
AB - Statement of Purpose. Type 1 diabetes (T1D) results in the T cell-mediated destruction of the insulin-producing β cells in the pancreas. β cell replacement by way of donor islet transplantation would allay the problems associated with the disease but requires systemic immunosuppression for graft function and survival. Due to immune suppression, islet transplantation is only indicated for a fraction of patients with T1D. Islet encapsulation strives to protect the donor tissue by preventing direct contact with host immune cells. While such strategies have exhibited safety in clinical trials, long-term efficacy remains a lofty goal that is subverted by the large graft volumes, limited access to well vascularized sites, and increased barrier to diffusion associated with traditional microencapsulation. Conformal coating minimizes capsule thickness and graft volume, representing the next generation of encapsulated islet products (Fig. 1). Here, we hypothesize that the post-conformal coating viability and glucose-stimulated insulin secretion (GSIS) performance of islets may be increased by optimizing process parameters, materials, and recovery procedures associate with this platform.
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M3 - Conference contribution
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
ER -