Confirming an experimental therapy prior to transfer to humans: What is the ideal?

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

As the spinal cord injury (SCI) scientific community moves closer to translating experimental data to the clinic, specific steps should be addressed to improve our chances of success. Some of the steps under discussion include animal modeling, clinically relevant endpoints, compelling evidence for improvements, and safety issues. First, it will be beneficial if exciting data are first replicated before findings are considered clinically relevant. Then major findings must be published in peer-reviewed journals so that the scientific community may scrutinize the data. Finally, continued communication between different research groups throughout the world, as well as between basic scientists and clinicians working in the area of SCI, will enhance our progress in this important research field.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalJournal of rehabilitation research and development
Volume40
Issue number4 SUPPL. 1
DOIs
StatePublished - 2003

Keywords

  • Animal models
  • Behavior
  • Electrophysiology
  • Human spinal cord injury (SCI)
  • Neuropathology
  • Neuroprotection
  • Outcome measures
  • Replication studies
  • Safety
  • Spinal cord trauma
  • Transplantation

ASJC Scopus subject areas

  • Rehabilitation
  • Health Professions(all)
  • Engineering(all)

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