Confirmation of association between D10S583 and Alzheimer's disease in a case-control sample

G. Ait-Ghezala, L. Abdullah, R. Crescentini, F. Crawford, T. Town, S. Singh, D. Richards, R. Duara, M. Mullan

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Several independent studies have reported that loci on chromosome 10 are associated/linked with Alzheimer's disease (AD), including a family-based study demonstrating an association between the marker D10S583 and AD. We have examined the D10S583 polymorphic marker and apolipoprotein E (APOE) gene in a case-control study. We observed the expected association of the APOE allele ε4 with AD, and an inverse association between the D10S583 allele 209 and AD. These data support the original findings that suggest the presence of a candidate gene for AD in this region of chromosome 10. The nearby insulin degrading enzyme gene has been previously proposed as a candidate gene; however, a number of other putative candidate genes are also located in this region. The ongoing investigation of the genetic source of association and linkage in this region is clearly warranted.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalNeuroscience Letters
Volume325
Issue number2
DOIs
StatePublished - Jun 7 2002

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • D10S583
  • Dinucleotide repeat
  • Genetic association

ASJC Scopus subject areas

  • Neuroscience(all)

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