Cone damage in patients receiving high-dose irofulven treatment

Michael S. Lee, Nisha Gupta, Richard T. Penson, John Loewenstein, Meredith S. Wepner, Michael V. Seiden, Ann H. Milam

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives: To describe the clinical, perimetric, and electroretinographic (ERG) results of 4 patients with cone dysfunction following irofulven treatment including the histopathologic and immunocytochemical features of one patient's retinas. Design: Observational case series. Methods: The patients were examined clinically, including perimetric and ERG evaluations. Eyes from patient 1 and healthy postmortem eyes were processed for histopathologic and immunocytochemistry studies with antibodies specific for cones, rods, and reactive Müller cells. Main Outcome Measures: Clinical signs and symptoms, perimetry, ERG, retinal histopathologic and immunocytochemistry study results. Results: All 4 patients had ERG changes consistent with abnormal cone responses and relatively normal rod responses. Compared with control eyes, the retina of patient 1 had approximately half the normal numbers of macular cones and fewer peripheral cones. The number of rods were normal but all rod and cone outer segments were shortened. Conclusion: High-dose irofulven treatment causes cone-specific damage with relative sparing of rods.

Original languageEnglish (US)
Pages (from-to)29-34
Number of pages6
JournalArchives of Ophthalmology
Volume123
Issue number1
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

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Vertebrate Photoreceptor Cells
Retina
Therapeutics
Immunohistochemistry
Rod Cell Outer Segment
Visual Field Tests
Signs and Symptoms
irofulven
Outcome Assessment (Health Care)
Antibodies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Lee, M. S., Gupta, N., Penson, R. T., Loewenstein, J., Wepner, M. S., Seiden, M. V., & Milam, A. H. (2005). Cone damage in patients receiving high-dose irofulven treatment. Archives of Ophthalmology, 123(1), 29-34. https://doi.org/10.1001/archopht.123.1.29

Cone damage in patients receiving high-dose irofulven treatment. / Lee, Michael S.; Gupta, Nisha; Penson, Richard T.; Loewenstein, John; Wepner, Meredith S.; Seiden, Michael V.; Milam, Ann H.

In: Archives of Ophthalmology, Vol. 123, No. 1, 01.01.2005, p. 29-34.

Research output: Contribution to journalArticle

Lee, MS, Gupta, N, Penson, RT, Loewenstein, J, Wepner, MS, Seiden, MV & Milam, AH 2005, 'Cone damage in patients receiving high-dose irofulven treatment', Archives of Ophthalmology, vol. 123, no. 1, pp. 29-34. https://doi.org/10.1001/archopht.123.1.29
Lee MS, Gupta N, Penson RT, Loewenstein J, Wepner MS, Seiden MV et al. Cone damage in patients receiving high-dose irofulven treatment. Archives of Ophthalmology. 2005 Jan 1;123(1):29-34. https://doi.org/10.1001/archopht.123.1.29
Lee, Michael S. ; Gupta, Nisha ; Penson, Richard T. ; Loewenstein, John ; Wepner, Meredith S. ; Seiden, Michael V. ; Milam, Ann H. / Cone damage in patients receiving high-dose irofulven treatment. In: Archives of Ophthalmology. 2005 ; Vol. 123, No. 1. pp. 29-34.
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