Cone damage in patients receiving high-dose irofulven treatment

Michael S. Lee, Nisha Gupta, Richard T. Penson, John Loewenstein, Meredith S. Wepner, Michael V. Seiden, Ann H. Milam

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objectives: To describe the clinical, perimetric, and electroretinographic (ERG) results of 4 patients with cone dysfunction following irofulven treatment including the histopathologic and immunocytochemical features of one patient's retinas. Design: Observational case series. Methods: The patients were examined clinically, including perimetric and ERG evaluations. Eyes from patient 1 and healthy postmortem eyes were processed for histopathologic and immunocytochemistry studies with antibodies specific for cones, rods, and reactive Müller cells. Main Outcome Measures: Clinical signs and symptoms, perimetry, ERG, retinal histopathologic and immunocytochemistry study results. Results: All 4 patients had ERG changes consistent with abnormal cone responses and relatively normal rod responses. Compared with control eyes, the retina of patient 1 had approximately half the normal numbers of macular cones and fewer peripheral cones. The number of rods were normal but all rod and cone outer segments were shortened. Conclusion: High-dose irofulven treatment causes cone-specific damage with relative sparing of rods.

Original languageEnglish (US)
Pages (from-to)29-34
Number of pages6
JournalArchives of ophthalmology
Volume123
Issue number1
DOIs
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'Cone damage in patients receiving high-dose irofulven treatment'. Together they form a unique fingerprint.

  • Cite this

    Lee, M. S., Gupta, N., Penson, R. T., Loewenstein, J., Wepner, M. S., Seiden, M. V., & Milam, A. H. (2005). Cone damage in patients receiving high-dose irofulven treatment. Archives of ophthalmology, 123(1), 29-34. https://doi.org/10.1001/archopht.123.1.29