Condylomatous carcinoma of the vulva with special reference to human papillomavirus DNA

Gordon O. Downey, Takashi Okagakl, Ronald S. Ostrow, Barbara A. Clark, Leo B. Twiggs, Anthony J. Faras

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Nine cases of condylomatous carcinoma (squamous cell carcinoma arising in condyloma acuminatum) of the vulva were studied for their clinical history, histopathology, and presence of human papillomavirus (HPV) DNA. Condylomatous carcinoma occurred primarily in an elderly population with a mean age of 70 years. There was an antecedent history of vulvar condyloma in 77%, with a median of nine months before the documentation of an invasive lesion. The disease had a good prognosis, with few recurrences and no metastasis or deaths from the disease. Human papillomavirus DNA was demonstrated to be present in 55% of these tumors by either filter or in situ hybridization techniques. Both HPV 6 and HPV 16 DNA were identified in an equal number of cases.

Original languageEnglish (US)
Pages (from-to)68-73
Number of pages6
JournalObstetrics and gynecology
Volume72
Issue number1
StatePublished - Jul 1988
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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