Concurrent presence of secretory carcinoma and Warthin's tumor in ipsilateral parotid gland

Arshad Kaleem, Neel Patel, Shadi Alzahrani, Hisham Hatoum, Ramzey Tursun

Research output: Contribution to journalLetterpeer-review

2 Scopus citations


Background: The presence of synchronous benign and malignant salivary gland neoplasms is very rare. The authors present a previously unreported combination of Secretory Carcinoma (SC) and Warthin's Tumor (WT) within the same parotid gland. Methods: The patient presented with increasingly painful enlargement of the left parotid gland. CT scan with contrast revealed a heterogeneous solid/cystic mass in the superficial lobe. Fine needle aspiration cytology favored pleomorphic adenoma (PA) and patient underwent superficial parotidectomy without complication. Results: Final pathology revealed concomitant presence of SC and WT. Stains were positive for S100 and mammaglobin, and FISH revealed the presence of t(12;15) (p13;q25) translocation, resulting in the ETV6-NTRK3 fusion gene. Conclusion: It is important for surgeons and pathologists to note the potential for co-existing benign and malignant pathology within the same salivary gland, as this can have an impact on management and prognosis for patients.

Original languageEnglish (US)
Article number104691
JournalOral oncology
StatePublished - Oct 2020


  • Parotid gland
  • Salivary tumors
  • Secretory carcinoma
  • Synchronous
  • Warthin's tumor

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research


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