Concurrent presence of secretory carcinoma and Warthin's tumor in ipsilateral parotid gland

Arshad Kaleem, Neel Patel, Shadi Alzahrani, Hisham Hatoum, Ramzey Tursun

Research output: Contribution to journalLetterpeer-review

2 Scopus citations

Abstract

Background: The presence of synchronous benign and malignant salivary gland neoplasms is very rare. The authors present a previously unreported combination of Secretory Carcinoma (SC) and Warthin's Tumor (WT) within the same parotid gland. Methods: The patient presented with increasingly painful enlargement of the left parotid gland. CT scan with contrast revealed a heterogeneous solid/cystic mass in the superficial lobe. Fine needle aspiration cytology favored pleomorphic adenoma (PA) and patient underwent superficial parotidectomy without complication. Results: Final pathology revealed concomitant presence of SC and WT. Stains were positive for S100 and mammaglobin, and FISH revealed the presence of t(12;15) (p13;q25) translocation, resulting in the ETV6-NTRK3 fusion gene. Conclusion: It is important for surgeons and pathologists to note the potential for co-existing benign and malignant pathology within the same salivary gland, as this can have an impact on management and prognosis for patients.

Original languageEnglish (US)
Article number104691
JournalOral oncology
Volume109
DOIs
StatePublished - Oct 2020

Keywords

  • Parotid gland
  • Salivary tumors
  • Secretory carcinoma
  • Synchronous
  • Warthin's tumor

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

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